INTERSPECIES COMPARISONS OF INSITU INTRINSIC MECHANICAL-PROPERTIES OF DISTAL FEMORAL CARTILAGE
INTERSPECIES COMPARISONS OF INSITU INTRINSIC MECHANICAL-PROPERTIES OF DISTAL FEMORAL CARTILAGE
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DOI：
10.1002/jor.1100090304
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发表时间：
1991-05-01
影响因子：
2.8
通讯作者：
MOW, VC
中科院分区：
文献类型：
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作者：
ATHANASIOU, KA;ROSENWASSER, MP;MOW, VC
我们测量了5种动物（牛、犬、人、猴和兔）膝关节软骨的原位生物力学特性，以研究人类膝关节损伤和骨关节炎动物模型的生物力学相关性。原位双相蠕变压痕实验进行，同时确定所有三个固有的材料系数（总模量，泊松比，和渗透性）的软骨所代表的线性KLM双相模型。此外，我们还评估了在股骨远端的“高”和“低”负重区域，负重对这些固有特性的影响。我们的结果表明，物种和地点之间的某些材料特性存在显着差异。每个物种内的髌骨前沟的总模量是最低的所有测试的网站，髌骨沟软骨的渗透性是最高的，并没有不同物种之间的变化。同样地，除了兔子外，所有物种的髌骨沟的泊松比都是最低的。这些结果导致的结论是，髌骨沟软骨可以承受更大和更快的压缩。因此，在高压缩载荷下，髌骨沟表面的软骨可以更快速地压缩以产生一致的髌股关节关节。对于任何给定的位置，在所有物种之间的骨料模量没有差异，并没有发现骨料模量和厚度之间的相关性在测试现场。因此，在选择合适的人类关节软骨实验动物模型的过程中，必须考虑到力学性能的显著种间差异。
We measured the in situ biomechanical properties of knee joint cartilage from five species (bovine, canine, human, monkey, and rabbit) to examine the biomechanical relevance of animal models of human knee joint injuries and osteoarthritis. In situ biphasic creep indentation experiments were performed to simultaneously determine all three intrinsic material coefficients (aggregate modulus, Poisson's ratio, and permeability) of the cartilage as represented by the linear KLM biphasic model. In addition, we also assessed the effects of load bearing on these intrinsic properties at "high" and "low" weight-bearing regions on the distal femur. Our results indicate that significant differences exist in some of these material properties among species and sites. The aggregate modulus of the anterior patellar groove within each species is the lowest among all sites tested, and the permeability of the patellar groove cartilage is the highest and does not vary among species. Similarly, the Poisson's ratio in the patellar groove is the lowest in all species, except in the rabbit. These results lead to the conclusion that patellar groove cartilage can undergo greater and faster compression. Thus, under high compressive loads, the cartilage of the patellar groove surface can more rapidly compress to create a congruent patellofemoral joint articulation. For any given location, no differences were found in the aggregate modulus among all the species, and no correlation was found between aggregate modulus and thickness at the test site. Thus, in the process of selecting a suitable experimental animal model of human articular cartilage, it is essential to consider the significant interspecies differences of the mechanical properties.