Haemostatic factors and prevalent coronary heart disease; the FINRISK Haemostasis Study.
Haemostatic factors and prevalent coronary heart disease; the FINRISK Haemostasis Study.
复制标题
止血因素与流行的冠心病；
DOI：
10.1093/oxfordjournals.eurheartj.a060387
复制
发表时间：
1994
影响因子：
39.3
通讯作者：
C. Ehnholm
中科院分区：
文献类型：
--
作者：
V. Salomaa;Vesa Rasi;Juha Pekkanen;E. Vahtera;M. Jauhiainen;Erkki Vartiainen;G. Myllylä;C. Ehnholm
我们在基于人群的FINRISK止血研究中检查了止血因素与冠心病（CHD）患病率的相关性。在2365名45-64岁的参与者中，确定了88名男性和44名女性患有冠心病。冠心病患者年龄较大，高密度脂蛋白胆固醇较低，甘油三酯较高，体重指数高于非冠心病患者。冠心病患者血浆纤维蛋白原（P < 0.0001，年龄和吸烟校正）和脂蛋白（a）（Lp（a），P = 0.001，年龄校正）浓度显著高于非冠心病患者。在女性中，结果与男性一致，但只有纤维蛋白原达到传统水平的统计学意义（P = 0.04）。在因子VII抗原、因子VII活性或纤溶酶原中未观察到差异。Lp（a）与冠心病的关系依赖于纤维蛋白原浓度（交互作用项P = 0.02）和非HDL胆固醇浓度（交互作用项P = 0.01）。这些横断面结果不能证明因果关系，但它们表明，在高脂蛋白（a）、纤维蛋白原和非高密度脂蛋白胆固醇人群中，冠心病的患病率有相当大的积累。
We examined the association of haemostatic factors with prevalent coronary heart disease (CHD) in the population-based FINRISK Haemostasis Study. Of the 2365 participants aged 45-64 years, 88 men and 44 women with prevalent CHD were identified. The participants with CHD were older and had lower high density lipoprotein cholesterol, higher triglycerides and higher body mass index than the participants without CHD. Men with CHD had significantly higher plasma fibrinogen (P < 0.0001, adjusted for age and smoking) and lipoprotein (a) (Lp (a), P = 0.001, adjusted for age) concentrations than those without CHD. Among women, the findings were consistent with those of men, but only fibrinogen reached the conventional level of statistical significance (P = 0.04). No difference was observed in factor VII antigen, factor VII activity or in plasminogen. The association of Lp (a) with prevalent CHD was dependent on fibrinogen concentration (P = 0.02 for the interaction-term) and on non-HDL cholesterol concentration (P = 0.01 for the interaction-term). These cross-sectional results do not prove causality, but they demonstrate a considerable accumulation of prevalent CHD among persons with high Lp (a), fibrinogen and non-HDL cholesterol.