Micro-computed tomography enables rapid surgical margin assessment during breast conserving surgery (BCS): correlation of whole BCS micro-CT readings to final histopathology
Micro-computed tomography enables rapid surgical margin assessment during breast conserving surgery (BCS): correlation of whole BCS micro-CT readings to final histopathology
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DOI：
10.1007/s10549-018-4951-3
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发表时间：
2018-12-01
影响因子：
3.8
通讯作者：
Pogue, Brian W.
中科院分区：
文献类型：
--
作者：
McClatchy, David M., III;Zuurbier, Rebecca A.;Pogue, Brian W.
大约23%的保乳手术（BCS）患者由于手术边缘病理阳性而接受第二次再切除手术。我们研究了微计算机断层扫描（micro-CT）作为BCS手术切缘指导工具的可行性和潜在价值。方法32例BCS标本在到达外科病理实验室后，采用临床前微ct系统进行前瞻性成像。重建的微ct扫描由经验丰富的乳腺放射科医生回顾性评估，他提供了病变是否扩展到标本边缘的二元确定。然后将这些读数与最终病理诊断和二维标本放射照相读数进行比较。结果32例肿瘤病理诊断为恶性28例，良性4例。32例标本中有5例（4例为恶性，1例为良性）病变组织延伸至边缘。对所有32个标本进行显微ct重建计算(
BackgroundRoughly 23% of breast conserving surgery (BCS) patients undergo a second re-excision procedure due to pathologically positive surgical margins. We investigated the feasibility and potential value of micro-Computed Tomography (micro-CT) as a surgical margin guidance tool during BCS.MethodsA cohort of 32 BCS specimens was prospectively imaged with a pre-clinical micro-CT system upon arrival in the surgical pathology laboratory. Reconstructed micro-CT scans were evaluated retrospectively by an experienced breast radiologist, who provided binary determinations whether lesions extended to the specimen margin. These readings were then compared to the final pathological diagnosis and to 2D specimen radiography readings.ResultsOf the 32 specimens imaged, 28 had malignant and four had benign pathological diagnoses. Overall five (four malignant, one benign) of the 32 specimens had lesion tissue extending to the margin. For all 32 specimens, micro-CT reconstructions were calculated (