Development and validation of a new, simplified endoscopic activity score for Crohn's disease: the SES-CD
Development and validation of a new, simplified endoscopic activity score for Crohn's disease: the SES-CD
复制标题
DOI：
10.1016/s0016-5107(04)01878-4
复制
发表时间：
2004-10-01
影响因子：
7.7
通讯作者：
Rutgeerts, P
中科院分区：
文献类型：
--
作者：
Daperno, M;D'Haens, G;Rutgeerts, P
背景粘膜病变的愈合似乎提供了显着的好处，是一个重要的治疗克罗恩病的临床试验的终点。目前唯一有效的内镜活动评分是克罗恩病内镜严重程度指数，该指数复杂且耗时，因此不适合常规使用。本研究的目的是开发和前瞻性地验证一个简单的内镜评分的疾病活动，简单的内镜评分克罗恩病。方法：选定的内镜参数（溃疡大小，溃疡和受影响的表面，狭窄）进行了评分从0到3。通过71次检查（其中内窥镜医生与观察员配对）来评估这些参数评分的重现性。最简单的分数（简单的克罗恩病内镜评分），这是高度相关的克罗恩病内镜指数的严重程度和克罗恩病的活动指数，70例患者，然后进行了前瞻性验证，在121个不同的患者与克罗恩病。结果：观察者之间的协议，所有选定的内镜变量是优秀的（kappa系数0.791-1.000）。基于多元线性回归，克罗恩病的简单内窥镜评分得出了溃疡大小、溃疡表面、受影响表面和管腔狭窄的评分总和。在研究的验证阶段，证实克罗恩病的简易内镜评分与克罗恩病内镜严重程度指数具有强相关性（r = 0.920）。此外，克罗恩病的简单内镜评分与临床参数和血清C-反应蛋白水平相关。结论：克罗恩病的简单内镜评分是一种简单，可重复，易于使用的克罗恩病内镜评分系统。
Background. Healing of mucosal lesions appears to offer significant benefit and is an important end point in clinical trials of treatment for Crohn's disease. The only validated endoscopic activity score at present is the Crohn's Disease Endoscopic Index of Severity, which is complicated and time consuming and, hence, is unsuitable for routine use. The aim of this study was to develop and to prospectively validate a simpler endoscopic score of disease activity, the Simple Endoscopic Score for Crohn's Disease.Methods: Selected endoscopic parameters (ulcer size, ulcerated and affected surfaces, stenosis) were scored from 0 to 3. Reproducibility for scoring of these parameters was evaluated through 71 examinations in which the endoscopist was paired with an observer. The simplest score (Simple Endoscopic Score for Crohn's Disease) that was highly correlated with both the Crohn's Disease Endoscopic Index of Severity and Crohn's Disease Activity Index was derived for 70 patients and then was prospectively validated in 121 different patients with Crohn's disease.Results: The interobserver agreement for all selected endoscopic variables was excellent (kappa coefficient 0.791-1.000). Based on multiple linear regression, the Simple Endoscopic Score for Crohn's Disease resulted in the sum of the scores for ulcer size, ulcerated surface, affected surface, and luminal narrowing. In the validation phase of the study, a strong correlation was demonstrated for the Simple Endoscopic Score for Crohn's Disease with Crohn's Disease Endoscopic Index of Severity (r = 0.920). In addition, the Simple Endoscopic Score for Crohn's Disease was correlated to clinical parameters and serum C-reactive protein level.Conclusions: Simple Endoscopic Score for Crohn's Disease is a simple, reproducible, and easy-to-use endoscopic scoring system for Crohn's disease.