Functional network changes and cognitive control in schizophrenia.
Functional network changes and cognitive control in schizophrenia.
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DOI：
10.1016/j.nicl.2017.05.001
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Carter CS
中科院分区：
文献类型：
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作者：
Ray KL;Lesh TA;Howell AM;Salo TP;Ragland JD;MacDonald AW;Gold JM;Silverstein SM;Barch DM;Carter CS
认知控制是一种认知和神经机制，有助于管理日常生活的复杂需求。研究表明，认知控制相关脑回路的功能障碍导致精神分裂症患者出现更大范围的认知缺陷。为了研究这一问题，我们评估了健康成人和精神分裂症患者在执行两个不同认知领域（RiSE情景记忆任务和DPX目标维持任务）任务时的功能连接网络，这两个领域对认知控制的需求不同。我们描述了精神分裂症对扩展额顶叶网络（FPN）功能连通性的一般和认知控制特异性影响，并使用图分析量化了网络拓扑特性。利用基于网络的统计（NBS），我们观察到两组FPN在两项任务中认知控制要求条件下的网络功能连通性更大，并证明了FPN对任务独立听觉网络的认知控制特异性。国家统计局的分析还显示，精神分裂症患者在所有任务中都存在广泛的连接缺陷。此外，网络拓扑的定量变化与诊断状态和任务需求有关。目前的研究结果，在一项仅限于正确试验的分析中，确保受试者处于任务状态，为认知控制的关键网络连接以及大脑网络重组以支持这种控制的方式提供了重要的见解。这种机制的损伤存在于精神分裂症中，这些结果强调了认知控制缺陷如何促进这种疾病的病理生理。FPN的功能连接变化支持认知控制的有效期。精神分裂症患者在所有认知控制任务中都观察到功能连通性下降。NBS识别的PFC和MTL节点表现出组间相互作用效应。观察到FPN拓扑结构与诊断状态和任务需求相关的变化。
Cognitive control is a cognitive and neural mechanism that contributes to managing the complex demands of day-to-day life. Studies have suggested that functional impairments in cognitive control associated brain circuitry contribute to a broad range of higher cognitive deficits in schizophrenia. To examine this issue, we assessed functional connectivity networks in healthy adults and individuals with schizophrenia performing tasks from two distinct cognitive domains that varied in demands for cognitive control, the RiSE episodic memory task and DPX goal maintenance task. We characterized general and cognitive control-specific effects of schizophrenia on functional connectivity within an expanded frontal parietal network (FPN) and quantified network topology properties using graph analysis. Using the network based statistic (NBS), we observed greater network functional connectivity in cognitive control demanding conditions during both tasks in both groups in the FPN, and demonstrated cognitive control FPN specificity against a task independent auditory network. NBS analyses also revealed widespread connectivity deficits in schizophrenia patients across all tasks. Furthermore, quantitative changes in network topology associated with diagnostic status and task demand were observed. The present findings, in an analysis that was limited to correct trials only, ensuring that subjects are on task, provide critical insights into network connections crucial for cognitive control and the manner in which brain networks reorganize to support such control. Impairments in this mechanism are present in schizophrenia and these results highlight how cognitive control deficits contribute to the pathophysiology of this illness. Functional connectivity changes in the FPN support effective periods of cognitive control. Decreased functional connectivity in schizophrenia was observed in all cognitive control tasks. The NBS identified nodes in the PFC and MTL exhibited group by control interaction effects. Changes in FPN topology associated with diagnostic status and task demand were observed.