N-versus C-terminal control over the screw-sense preference of the configurationally achiral, conformationally helical peptide motif Aib(8)GlyAib(8).
N-versus C-terminal control over the screw-sense preference of the configurationally achiral, conformationally helical peptide motif Aib(8)GlyAib(8).
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DOI：
10.1021/ja100662d
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发表时间：
2010-03
影响因子：
15
通讯作者：
Jordi Solà;M. Helliwell;J. Clayden
中科院分区：
文献类型：
--
作者：
Jordi Solà;M. Helliwell;J. Clayden
位于N-末端的单个手性残基对非手性氨基酸螺旋17-聚体AIB(8)GlyAib(8)的螺旋构象控制优于位于C-末端的单个氨基酸。X射线结晶学研究表明，Alb(8)GlyAlb(8)形成了迄今为止结晶学上观察到的最长的3(10)螺旋结构。
Conformational control over the screw sense of a helical 17-mer of achiral amino acids, Aib(8)GlyAib(8), from a single chiral residue located at the N-terminus is better than that from a single amino acid located at the C-terminus. X-ray crystallography indicates that Aib(8)GlyAib(8) forms the longest 3(10) helical structure observed crystallographically to date.