Challenges and opportunities in dermal/transdermal delivery.
Challenges and opportunities in dermal/transdermal delivery.
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DOI：
10.4155/tde.10.16
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发表时间：
2010-07
影响因子：
4.2
通讯作者：
Stinchcomb AL
中科院分区：
文献类型：
--
作者：
Paudel KS;Milewski M;Swadley CL;Brogden NK;Ghosh P;Stinchcomb AL
经皮给药是一个令人兴奋和具有挑战性的领域。目前市场上有许多透皮给药系统。然而，透皮吸收市场仍然局限于狭窄的药物范围。透皮给药方面的进一步进展取决于是否有能力克服药物分子的渗透性和皮肤刺激性所面临的挑战。促进皮肤渗透的新技术的出现和减轻皮肤刺激性的方法的发展将扩大亲水性化合物、大分子和用于新治疗适应症的传统药物的经皮市场。从正在进行的针对不同临床条件的各种药物的临床试验中可以看出，药物经皮给药有着广阔的前景。
Transdermal drug delivery is an exciting and challenging area. There are numerous transdermal delivery systems currently available on the market. However, the transdermal market still remains limited to a narrow range of drugs. Further advances in transdermal delivery depend on the ability to overcome the challenges faced regarding the permeation and skin irritation of the drug molecules. Emergence of novel techniques for skin permeation enhancement and development of methods to lessen skin irritation would widen the transdermal market for hydrophilic compounds, macromolecules and conventional drugs for new therapeutic indications. As evident from the ongoing clinical trials of a wide variety of drugs for various clinical conditions, there is a great future for transdermal delivery of drugs.