Air pollution during pregnancy and lung function in newborns: a birth cohort study
Air pollution during pregnancy and lung function in newborns: a birth cohort study
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DOI：
10.1183/09031936.00084008
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发表时间：
2009-03-01
影响因子：
24.3
通讯作者：
Frey, U.
中科院分区：
文献类型：
--
作者：
Latzin, P.;Roeoesli, M.;Frey, U.
产后接触空气污染与学龄期肺部生长减弱有关。目前作者的目的是确定产前接触空气污染是否与新生儿肺功能变化有关。 在一个由 241 名健康足月出生的新生儿组成的前瞻性出生队列中，在 5 周龄的未镇静睡眠期间测量了潮式呼吸、肺容量、通气不均匀性和呼出一氧化氮 (eNO)。对孕期母亲接触 50% 截止空气动力学直径为 10 μm 的颗粒物 (PM(10))、二氧化氮 (NO(2)) 和臭氧 (O(3)) 的情况以及距主要道路的距离进行了估计。使用线性回归评估这些暴露与肺功能之间的关联。产前 PM(10) 暴露较高（24.9 mL.min(-1)/mu g.m(-3) PM(10)）的婴儿每分钟通气量较高。产前 NO(2) 暴露量较高的婴儿的 eNO 增加（每亩 0.98 ppb g.m(-3) NO(2)）——产后暴露于空气污染并没有改变这些发现。未发现产前暴露于 O(3) 和肺功能参数之间存在关联。目前的结果表明，产前暴露于空气污染可能与新生儿较高的呼吸需求和气道炎症有关。早期肺部发育过程中的这种变化对于长期呼吸道疾病发病率可能很重要。
Post-natal exposure to air pollution is associated with diminished lung growth during school age. The current authors aimed to determine whether pre-natal exposure to air pollution is associated with lung function changes in the newborn.In a prospective birth cohort of 241 healthy term-born neonates, tidal breathing, lung volume, ventilation inhomogeneity and exhaled nitric oxide (eNO) were measured during unsedated sleep at age 5 weeks. Maternal exposure to particles with a 50% cut-off aerodynamic diameter of 10 mu m (PM(10)), nitrogen dioxide (NO(2)) and ozone (O(3)) and distance to major roads were estimated during pregnancy. The association between these exposures and lung function was assessed using linear regression.Minute ventilation was higher in infants with higher pre-natal PM(10) exposure (24.9 mL.min(-1) per mu g.m(-3) PM(10)). The eNO was increased in infants with higher pre-natal NO(2) exposure (0.98 ppb per mu g.m(-3) NO(2))- Post-natal exposure to air pollution did not modify these findings. No association was found for pre-natal exposure to O(3) and lung function parameters.The present results suggest that pre-natal exposure to air pollution might be associated with higher respiratory need and airway inflammation in newborns. Such alterations during early lung development may be important regarding long-term respiratory morbidity.