Effect of Propiomazine on Plasma Prolactin in the Rat: Counteraction by L-Dopa 1
Effect of Propiomazine on Plasma Prolactin in the Rat: Counteraction by L-Dopa 1
复制标题
丙哌嗪对大鼠血浆催乳素的影响：L-多巴 1 的抵消作用
DOI：
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发表时间：
1985
期刊：
影响因子：
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通讯作者：
S. Quadri
中科院分区：
文献类型：
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作者：
M. Fayez;H. H. Ahmed;S. Quadri
单次静脉注射0.31、0.62、1.25、2.5、5、10或20 mg/kg体重的吩噻嗪衍生物丙恶嗪（PP）给雄性大鼠，显著（P 0.05）增加血浆催乳素浓度。较高剂量（5、10和20 mg/kg体重）产生的增加幅度和持续时间均大于较低剂量产生的增加。较高剂量的PP，沿着血浆催乳素升高，也导致血浆促黄体生成素（LH）水平降低。用左旋多巴（100 mg/kg体重）预处理完全阻断了PP诱导的催乳素释放刺激，表明PP在下丘脑或垂体前叶水平的抗多巴胺能作用是其对催乳素释放的影响的原因。
Abstract A single iv injection of 0.31, 0.62, 1.25, 2.5, 5, 10, or 20 mg/kg body wt of a phenothiazine derivative, propiomazine (PP), into male rats significantly (P 0.05) increased plasma prolactin concentrations. The higher doses (5, 10, and 20 mg/kg body wt) produced increases that were greater in both magnitude and duration than those produced by the lower doses. The higher doses of PP, along with the elevations in plasma prolactin, also produced concomitant decreases in plasma luteinizing hormone (LH) levels. Pretreatment with l-dopa (100 mg/kg body wt) completely blocked the PP-induced stimulation of prolactin release, indicating that antidopaminergic action of PP either at the hypothalamic or anterior pituitary level was responsible for its effects on the release of prolactin.