Age-related decrease in cortical excitability circadian variations during sleep loss and its links with cognition
Age-related decrease in cortical excitability circadian variations during sleep loss and its links with cognition
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DOI：
10.1016/j.neurobiolaging.2019.02.004
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发表时间：
2019-06-01
影响因子：
4.2
通讯作者：
Vandewalle, Gilles
中科院分区：
文献类型：
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作者：
Gaggioni, Giulia;Ly, Julien Q. M.;Vandewalle, Gilles
皮质兴奋性依赖于睡眠-觉醒调节，是认知的核心，并与年龄相关的认知衰退有关。然而，大脑皮层兴奋性在老年人长时间清醒过程中的动力学尚不清楚。在这里，我们反复探讨大脑皮层的额叶皮层兴奋性，使用经颅磁刺激和脑电图在13个年轻人和12个老年人的健康参与者在睡眠剥夺。尽管不同年龄组的总体皮质兴奋性没有差异，但老年人在长时间觉醒期间皮质兴奋性变化的幅度会受到抑制。这种与年龄相关的抑制与减轻睡眠不足对执行功能的神经行为后果有关。此外，在老年人和年轻人中，更高的皮质兴奋性分别与更好和更低的执行性能潜在相关。在老年参与者中发现的皮质兴奋性动力学的抑制可能来自睡眠稳态和昼夜节律过程的影响减少。它可能反映了大脑适应性的降低，这是衰老中认知灵活性降低的基础。未来的研究应该确认皮质兴奋性和行为之间的初步联系，并解决维持皮质兴奋性动态是否可以抵消与年龄相关的认知能力下降。(C)2019爱思唯尔公司All rights reserved.
Cortical excitability depends on sleep-wake regulation, is central to cognition, and has been implicated in age-related cognitive decline. The dynamics of cortical excitability during prolonged wakefulness in aging are unknown, however. Here, we repeatedly probed cortical excitability of the frontal cortex using transcranial magnetic stimulation and electroencephalography in 13 young and 12 older healthy participants during sleep deprivation. Although overall cortical excitability did not differ between age groups, the magnitude of cortical excitability variations during prolonged wakefulness was dampened in older individuals. This age-related dampening was associated with mitigated neurobehavioral consequences of sleep loss on executive functions. Furthermore, higher cortical excitability was potentially associated with better and lower executive performance, respectively, in older and younger adults. The dampening of cortical excitability dynamics found in older participants likely arises from a reduced impact of sleep homeostasis and circadian processes. It may reflect reduced brain adaptability underlying reduced cognitive flexibility in aging. Future research should confirm preliminary associations between cortical excitability and behavior and address whether maintaining cortical excitability dynamics can counteract age-related cognitive decline. (C) 2019 Elsevier Inc. All rights reserved.