The self-obsession of T cells: how TCR signaling thresholds affect fate 'decisions' and effector function.
The self-obsession of T cells: how TCR signaling thresholds affect fate 'decisions' and effector function.
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自我反应性曾经被认为是T细胞的一个潜在特征，通过克隆选择来消除这种特征，以保护宿主免受自身免疫病理的影响。我们现在意识到，T细胞的功能实际上是广泛的自我反应，甚至可以说是以自我为中心的。T细胞对自身配体的反应强度，以及这种反应发生的环境环境，几乎影响到T细胞生物学的方方面面：从发育到分化，再到效应器功能。在这篇综述中，我们重点介绍了与T细胞自身反应性有关的最新进展和发现，并特别强调了TCR信号阈值。
Self-reactivity was once seen as a potential characteristic of T cells that was eliminated by clonal selection to protect the host from autoimmune pathology. We now appreciate that the T cell repertoire is in fact, broadly self-reactive, one could even say self-centered. The strength with which a T cell reacts to self ligands, and the environmental context that this reaction occurs in, influences almost every aspect of T cell biology: from development to differentiation to effector function. In this review we highlight recent advances and discoveries that relate to T cell self-reactivity, with a particular emphasis on TCR signaling thresholds.
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