The effects of intra-amygdaloid infusions of a D2 dopamine receptor antagonist on Pavlovian fear conditioning.
The effects of intra-amygdaloid infusions of a D2 dopamine receptor antagonist on Pavlovian fear conditioning.
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D2 多巴胺受体拮抗剂杏仁核内输注对巴甫洛夫恐惧调节的影响。
DOI：
10.1037//0735-7044.114.3.647
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发表时间：
2000
影响因子：
1.9
通讯作者：
Kapp,BS
中科院分区：
文献类型：
--
作者：
Guarraci,FA;Frohardt,RJ;Falls,WA;Kapp,BS
本研究探讨了双侧杏仁核内输注D β受体拮抗剂依替氯必利对巴甫洛夫恐惧条件反射的获得和表达的影响，通过在大鼠中冻结声学和背景刺激来测量。在采集前或采集和保留测试前输注依替氯必利显著减弱了24小时后保留测试期间的条件冻结至音调呈现。然而，没有观察到任何影响，在收购过程中出现的冻结。此外，这些影响并不归因于状态依赖性学习效应或基线活动或休克反应性的改变。总之，这些结果表明，D受体的杏仁体多巴胺传递有助于恐惧记忆的形成和/或巩固（PsycINFO数据库记录（c）2016阿帕，保留所有权利）
The present study examined the effects of bilateral intra-amygdaloid infusions of the D₂ receptor antagonist, eticlopride, on the acquisition and expression of Pavlovian fear conditioning as measured by freezing to acoustic and background contextual stimuli in the rat. Infusions of eticlopride before acquisition or before both acquisition and retention testing significantly attenuated conditioned freezing to tone presentations during the retention test 24 hr later. No effects, however, were observed on freezing that emerged during acquisition. Furthermore, these effects were not attributable to state-dependent learning effects or alterations in baseline activity or shock reactivity. In conclusion, these results suggest that amygdaloid dopamine transmission at D₂ receptors contributes to the formation and/or consolidation of fear memories (PsycINFO Database Record (c) 2016 APA, all rights reserved)