Comparison of PGSE and STEAM DTI acquisitions with varying diffusion times for probing anisotropic structures in human kidneys
Comparison of PGSE and STEAM DTI acquisitions with varying diffusion times for probing anisotropic structures in human kidneys
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不同扩散时间的 PGSE 和 STEAM DTI 采集用于探测人体肾脏各向异性结构的比较
DOI：
10.1002/mrm.28217
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发表时间：
2020
影响因子：
3.3
通讯作者：
Wittsack H-J
中科院分区：
文献类型：
--
作者：
Stabinska J;Ljimani A;Frenken M;Feiweier T;Lanzman RS;Wittsack H-J
目的评价不同扩散时间的受激回波采集模式(STEAM)和脉冲梯度自旋回波(PGSE)扩散张量成像(DTI)在测量肾组织各向异性方面的敏感性。方法12名健康志愿者在3T扫描机上进行磁共振检查，包括STEAM和脉冲梯度自旋回波扩散张量成像，扩散时间Δ分别为20.3、37和125ms。对三名志愿者进行了两次扫描，以测试重复检查的重复性。计算自动分割的双肾皮质和髓质感兴趣区的扩散参数分数各向异性(FA)和表观扩散系数(ADC)，并对所有受试者进行平均，以便进一步分析。结果STEAM序列的皮质-髓质差值明显高于短∆序列(∆=0.001)和中等扩散时间的PGSE(P<；=0.05)。FA/ADC测量的重复性非常好，对于所研究的所有采集模式都具有可比性。在FA图上，扩散时间居中的PGSE序列在放射科医生的主观视觉评价中得分最高。结论肾组织各向异性的划分取决于DTI序列的扩散时间。扩散时间约为37ms的PGSE采集提供了可重现的结果，在FA和ADC图中具有最佳的皮髓对比度，并具有良好的图像质量。
PurposeTo evaluate the sensitivity of stimulated‐echo acquisition mode (STEAM) and pulsed‐gradient spin‐echo (PGSE) diffusion tensor imaging (DTI) acquisitions with different diffusion times for measuring renal tissue anisotropy.MethodsTwelve healthy volunteers underwent an MRI examination at a 3T scanner including STEAM and PGSE DTI with variable diffusion times Δ (20.3, 37 and 125 ms). Three volunteers were scanned twice to test the reproducibility for repeated examinations. Diffusion parameters fractional anisotropy (FA) and apparent diffusion coefficient (ADC) in the automatically segmented cortical and medullary regions of interests in both kidneys were calculated and averaged over all subjects for further analysis. Moreover, 5‐grade qualitative evaluation of the FA and ADC maps from each sequence was conducted by two experienced radiologists in a consensus.ResultsThe cortex‐medulla difference in the STEAM sequence was significantly higher than that in PGSE with short ∆ = 20.3 ms (P< 0.001) and in PGSE with intermediate ∆ = 37 ms (P< 0.05) diffusion times. Reproducibility of the FA/ADC measurements was very good and comparable for all acquisition modes investigated. For the FA maps, the PGSE sequence with intermediate diffusion time scored highest in the subjective visual assessment of radiologists.ConclusionThe delineation of anisotropy in renal tissue is depending on the used diffusion time of the DTI sequence. A PGSE acquisition at a diffusion time of about 37 ms provides reproducible results with optimal corticomedullary contrast in FA and ADC maps and good image quality.
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DOI：
--
发表时间：
1966
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
C. Tisher;R. Bulger;B. Trump
通讯作者：
B. Trump
受激回波的扩散成像：信号模型和实验设计
DOI：
--
发表时间：
2013
期刊：
影响因子：
--
作者：
D. Alexander;T. Dyrby
通讯作者：
T. Dyrby
影响因子：
4.3
作者：
Layton, Anita T.;Layton, Harold E.
通讯作者：
Layton, Harold E.
DOI：
--
发表时间：
1966
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
C. E. Myers;R. Bulger;C. Tisher;B. Trump
通讯作者：
B. Trump
DOI：
--
发表时间：
1968
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
C. Tisher;R. Bulger;B. Trump
通讯作者：
B. Trump