The 20 years it took to recognize the importance of tiny RNAs.
The 20 years it took to recognize the importance of tiny RNAs.
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DOI：
10.1016/s0092-8674(04)00034-0
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发表时间：
2004-01-23
期刊：
影响因子：
64.5
通讯作者：
Ha, Ilho
中科院分区：
文献类型：
--
作者：
Ruvkun, Gary;Wightman, Bruce;Ha, Ilho
秀丽隐杆线虫中异时基因的遗传途径在幼虫发育过程中指定细胞的时间命运，从而控制不同胚胎后细胞系事件的时间和顺序（Ambros和Horvitz, 1984； Ambros和Horvitz, 1987; Ambros, 1989）。异慢性基因的突变可能导致早熟发育，即正常的晚期发育程序在幼虫早期表达，或发育迟缓，即正常的早期发育程序在后期重复（Chalfle等人）。, 1981;Ambros and Horvitz, 1984)。很可能特定细胞的阶段特异性发育程序的表达需要对异时基因产物进行精确的时间调节。lin-4在秀丽隐杆线虫幼虫发育早期起作用，影响基本上所有幼虫阶段和不同细胞类型的发育事件的时间(Chalfle等人，1981；
A genetic pathway of heterochronic genes in Caenorhabditis elegans acts to specify the temporal fates of cells during larval development, thereby controlling the timing and sequence of events in diverse postembryonic cell lineages (Ambros and Horvitz, 1984; Ambros and Horvitz, 1987; Ambros, 1989). Mutations in the heterochronic genes can cause either precocious development, in which normally late developmental programs are expressed at early larval stages, or retarded development, in which normally early developmental programs are reiterated at later stages (Chalfle et at., 1981; Ambros and Horvitz, 1984). It is likely that the expression of stage-specific developmental programs by particular cells requires the accurate temporal regulation of the products of the heterochronic genes. lin-4 acts early in C. elegans larval development to affect the timing of developmental events at essentially all larval stages and in diverse cell types (Chalfle et al., 1981;