A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms.
A Diet Mimicking Fasting Promotes Regeneration and Reduces Autoimmunity and Multiple Sclerosis Symptoms.
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DOI：
10.1016/j.celrep.2016.05.009
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发表时间：
2016-06-07
期刊：
影响因子：
8.8
通讯作者：
Longo VD
中科院分区：
文献类型：
--
作者：
Choi IY;Piccio L;Childress P;Bollman B;Ghosh A;Brandhorst S;Suarez J;Michalsen A;Cross AH;Morgan TE;Wei M;Paul F;Bock M;Longo VD
饮食干预在多发性硬化症（MS）的治疗中并不有效。在这里，我们表明，在小鼠实验性自身免疫性脑脊髓炎（EAE）模型中，禁食模仿饮食（FMD）的周期性3天循环在改善脱髓鞘和症状方面是有效的。FMD降低了所有小鼠的临床严重程度，并完全逆转了20%动物的症状。这些改善与皮质酮水平和Treg细胞数量增加，促炎细胞因子，TH1和TH17细胞以及抗原呈递细胞（APC）水平降低有关。此外，FMD促进少突胶质细胞前体细胞再生和轴突中的髓鞘再生，以响应EAE和cuprizone MS模型，支持其对自身免疫和髓鞘再生的抑制作用。我们还报告了初步数据，表明FMD或慢性生酮饮食在治疗复发缓解型多发性硬化症（RRMS）患者中是安全、可行和潜在有效的（NCT 01538355）。
Dietary interventions have not been effective in the treatment of multiple sclerosis (MS). Here we show that periodic 3 day cycles of a fasting mimicking diet (FMD) are effective in ameliorating demyelination and symptoms in a murine experimental autoimmune encephalomyelitis (EAE) model. The FMD reduced clinical severity in all mice, and completely reversed symptoms in 20% of the animals. These improvements were associated with increased corticosterone levels and Treg cell number, reduced levels of pro-inflammatory cytokines, TH1 and TH17 cells, and antigen presenting cells (APCs). Moreover, the FMD promoted oligodendrocyte precursor cell regeneration and remyelination in axons in response to both EAE and cuprizone MS models, supporting its effects on both suppression of autoimmunity and remyelination. We also report preliminary data suggesting that a FMD or a chronic ketogenic diet are safe, feasible and potentially effective in the treatment of relapsing remitting multiple sclerosis (RRMS) patients (NCT01538355).