Observational Research in Childhood Infectious Diseases (ORChID): a dynamic birth cohort study
Observational Research in Childhood Infectious Diseases (ORChID): a dynamic birth cohort study
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DOI：
10.1136/bmjopen-2012-002134
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发表时间：
2012-01-01
期刊：
影响因子：
2.9
通讯作者：
Grimwood, Keith
中科院分区：
文献类型：
--
作者：
Lambert, Stephen Bernard;Ware, Robert S.;Grimwood, Keith
导言：即使在发达经济体，传染病仍然是儿童早期疾病的最常见原因。我们目前对这些感染的流行病学的了解受到依赖于几十年前使用低敏感性实验室方法进行的数据以及最近报告的严重的医院管理疾病的研究的限制。方法和分析：儿童传染病观察性研究(兰花)研究是一项正在进行的研究，招募了动态出生队列，以记录儿童早期呼吸道和胃肠道病毒感染的社区流行病学。妇女在出生前就被招募，她们健康的新生儿在生命的头两年被跟踪。父母为被研究的孩子保留每天的症状日记，收集每周一次的前鼻拭子和肮脏的尿布拭子，并在孩子符合预先定义的疾病标准时完成负担日记。样本将通过实时聚合酶链式反应分析进行广泛的病毒检测。初步分析包括按年龄和季节性计算队列的急性呼吸道疾病(ARI)和急性胃肠炎(AGE)的发病率。当儿童没有症状时，来自他们的对照材料将使我们能够确定ARI和年龄的比例可以归因于特定的病原体。二次分析将评估特定呼吸道和胃肠道病原体的发病率和脱落持续时间。伦理和传播：这项研究由昆士兰儿童健康医院和卫生服务、皇家布里斯班和妇女医院以及昆士兰大学的人类研究伦理委员会批准。
Introduction: Even in developed economies infectious diseases remain the most common cause of illness in early childhood. Our current understanding of the epidemiology of these infections is limited by reliance on data from decades ago performed using low-sensitivity laboratory methods, and recent studies reporting severe, hospital-managed disease.Methods and analysis: The Observational Research in Childhood Infectious Diseases (ORChID) study is an ongoing study enrolling a dynamic birth cohort to document the community-based epidemiology of viral respiratory and gastrointestinal infections in early childhood. Women are recruited antenatally, and their healthy newborn is followed for the first 2 years of life. Parents keep a daily symptom diary for the study child, collect a weekly anterior nose swab and dirty nappy swab and complete a burden diary when a child meets pre-defined illness criteria. Specimens will be tested for a wide range of viruses by real-time PCR assays. Primary analyses involves calculating incidence rates for acute respiratory illness (ARI) and acute gastroenteritis (AGE) for the cohort by age and seasonality. Control material from children when they are without symptoms will allow us to determine what proportion of ARIs and AGE can be attributed to specific pathogens. Secondary analyses will assess the incidence and shedding duration of specific respiratory and gastrointestinal pathogens.Ethics and dissemination: This study is approved by The Human Research Ethics Committees of the Children's Health Queensland Hospital and Health Service, the Royal Brisbane and Women's Hospital and The University of Queensland.