Concise review: Engineering myocardial tissue: the convergence of stem cells biology and tissue engineering technology.
Concise review: Engineering myocardial tissue: the convergence of stem cells biology and tissue engineering technology.
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DOI：
10.1002/stem.1467
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发表时间：
2013-12
期刊：
影响因子：
5.2
通讯作者：
Domian, Ibrahim J.
中科院分区：
文献类型：
--
作者：
Buikema, Jan Willem;Van der Meer, Peter;Sluijter, Joost P. G.;Domian, Ibrahim J.
关键词：
晚期心力衰竭是发达国家的一个主要公共卫生问题。临床综合征是由存活和/或功能齐全的心肌组织的丧失引起的。设计新方法来增加衰竭心脏中功能正常的人类心肌细胞的数量，是现代再生心血管医学的基础。已经进行了许多临床试验，试图通过移植不同组的干细胞或祖细胞来增加功能性心肌细胞的数量。尽管有一些令人鼓舞的建议，表明早期治疗效果较小，但迄今为止，还没有证据表明细胞或组织植入牢固，这强调了对新方法的需求。具有临床意义的心脏再生需要识别最佳的心源性细胞类型并将其组装成在功能和电学上与天然心肌耦合的成熟心肌组织。我们在这里回顾干细胞生物学和组织工程的最新进展，并描述这两个领域的融合如何产生心脏再生的新方法。
Advanced heart failure represents a leading public health problem in the developed world. The clinical syndrome results from the loss of viable and/or fully functional myocardial tissue. Designing new approaches to augment the number of functioning human cardiac muscle cells in the failing heart serve as the foundation of modern regenerative cardiovascular medicine. A number of clinical trials have been performed in an attempt to increase the number of functional myocardial cells by the transplantation of a diverse group of stem or progenitor cells. Although there are some encouraging suggestions of a small early therapeutic benefit, to date, no evidence for robust cell or tissue engraftment has been shown, emphasizing the need for new approaches. Clinically meaningful cardiac regeneration requires the identification of the optimum cardiogenic cell types and their assembly into mature myocardial tissue that is functionally and electrically coupled to the native myocardium. We here review recent advances in stem cell biology and tissue engineering and describe how the convergence of these two fields may yield novel approaches for cardiac regeneration.
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DOI：
10.1126/science.1177350
发表时间：
2009-10-16
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Domian IJ;Chiravuri M;van der Meer P;Feinberg AW;Shi X;Shao Y;Wu SM;Parker KK;Chien KR
通讯作者：
Chien KR
影响因子：
15.9
作者：
Didie, Michael;Christalla, Peter;Zimmermann, Wolfram-Hubertus
通讯作者：
Zimmermann, Wolfram-Hubertus
影响因子：
24
作者：
Caspi, Oren;Huber, Irit;Gepstein, Lior
通讯作者：
Gepstein, Lior
影响因子：
20.1
作者：
Angst, BD;Khan, LUR;Gourdie, RG
通讯作者：
Gourdie, RG
影响因子：
64.5
作者：
Dong, Jixin;Feldmann, Georg;Pan, Duojia
通讯作者：
Pan, Duojia