Quantitative magnetization transfer imaging via selective inversion recovery with short repetition times
Quantitative magnetization transfer imaging via selective inversion recovery with short repetition times
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DOI：
10.1002/mrm.21143
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发表时间：
2007-02-01
影响因子：
3.3
通讯作者：
Gore, John C.
中科院分区：
文献类型：
--
作者：
Gochberg, Daniel F.;Gore, John C.
定量磁化传递成像（qMTI）方法能够估计基本的样品参数，如固体状的大分子质子池的相对大小和该池和直接测量的自由水质子之间的自旋交换率。一种这样的方法是选择性反转恢复（SIR），其中自由水质子被选择性地反转，并且信号被拟合到反转时间（TI）的双指数函数。SIR仅使用低功率脉冲，并且不需要单独的RF（B-1）或静态场（B-0）场图，并且分析在很大程度上独立于大分子池线形。这些都优于稳态非谐振饱和qMTI方法。然而，到目前为止，仅在重复时间TR >> T1的情况下实现SIR。本文介绍了一种修改的SIR具有更小的TR值和更大的信噪比（SNR）的效率。
Quantitative magnetization transfer imaging (qMTI) methods are able to estimate fundamental sample parameters, such as the relative size of the solid-like macromolecular proton pool and the spin exchange rate between this pool and the directly measured free water protons. One such method is selective inversion recovery (SIR), in which the free water protons are selectively inverted and the signal is fit to a biexponent a unction of the inversion time (TI). SIR uses only low-power pulses and requires no separate RF (B-1) or static field (B-0) field maps, and the analysis is largely independent of the macromolecular pool lineshape. These are all advantages over steady-state off-resonance saturation qMTI methods. However, up to now, SIR has been implemented only with repetition times TR >> T1. This paper describes a modification of SIR with smaller TR values and a greater signal-to-noise ratio (SNR) efficiency.