The Redox Code.
The Redox Code.
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DOI：
10.1089/ars.2015.6247
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发表时间：
2015-09-20
影响因子：
6.6
通讯作者：
Sies H
中科院分区：
文献类型：
--
作者：
Jones DP;Sies H
重要性：氧化还原密码是一组原则，定义了烟酰胺腺嘌呤二核苷酸（NAD，NADP）和硫醇/二硫化物和其他氧化还原系统以及硫醇氧化还原蛋白质组在生物系统中的空间和时间定位。该代码是丰富的阐述在氧依赖的生活，其中涉及O2和H2 O2的激活/失活循环有助于时空组织的分化，发展和适应环境。在氧化应激期间这种组织结构的破坏代表了系统故障和疾病的基本机制。最新进展：在生理条件下的氧化还原代码的评估组件的方法已经取得进展，允许洞察时空组织，并允许在氧化还原蛋白质组学和氧化还原代谢组学的氧化还原伙伴的识别。关键问题：氧化还原网络和氧化还原调节的复杂性正在逐步揭示，但仍有许多需要了解的。未来发展方向：在细胞和器官中定义的生理或病理条件下从氧化还原代码的原理产生的分子模式的详细知识将有助于理解健康和疾病中的氧化还原组分。最终，现代氧化还原医学将有科学依据。抗氧化剂。氧化还原信号。23、734-746。
Significance: The redox code is a set of principles that defines the positioning of the nicotinamide adenine dinucleotide (NAD, NADP) and thiol/disulfide and other redox systems as well as the thiol redox proteome in space and time in biological systems. The code is richly elaborated in an oxygen-dependent life, where activation/deactivation cycles involving O2 and H2O2 contribute to spatiotemporal organization for differentiation, development, and adaptation to the environment. Disruption of this organizational structure during oxidative stress represents a fundamental mechanism in system failure and disease. Recent Advances: Methodology in assessing components of the redox code under physiological conditions has progressed, permitting insight into spatiotemporal organization and allowing for identification of redox partners in redox proteomics and redox metabolomics. Critical Issues: Complexity of redox networks and redox regulation is being revealed step by step, yet much still needs to be learned. Future Directions: Detailed knowledge of the molecular patterns generated from the principles of the redox code under defined physiological or pathological conditions in cells and organs will contribute to understanding the redox component in health and disease. Ultimately, there will be a scientific basis to a modern redox medicine. Antioxid. Redox Signal. 23, 734–746.