Individual differences in anterior cingulate/paracingulate morphology are related to executive functions in healthy males
Individual differences in anterior cingulate/paracingulate morphology are related to executive functions in healthy males
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DOI：
10.1093/cercor/bhh004
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发表时间：
2004-04-01
期刊：
影响因子：
3.7
通讯作者：
Pantelis, C
中科院分区：
文献类型：
--
作者：
Fornito, A;Yücel, M;Pantelis, C
个体间皮层折叠变化的神经心理学相关性知之甚少。前扣带回（AC）皮质是一个具有相当大的变异性的区域，特别是关于扣带回旁沟（PCS），其仅存在于30-60%的个体中，并且更常见于左大脑半球。为了研究这种PCS不对称性的个体间差异是否与认知表现有关，我们将30名健康的右利手男性根据PCS在每个半球的发生率和程度分类为显示双折叠，双折叠或对称折叠模式，并比较他们在与额叶功能相关的执行认知过程任务上的表现。我们发现，更常见的PCSPCS不对称性与更好的表现在口头和非口头执行任务，但PCS的变异性没有影响的任务较少依赖于执行功能。这些结果表明，在认知要求高的执行功能任务的非特定性能优势，可能是由于AC/副扣带回皮层和连接的额叶区域之间的功能相互作用的差异，折叠的ESTA模式与。因此，大脑形态的正常变化似乎与认知能力的个体差异有关。
The neuropsychological correlates of inter-individual variations in cortical folding are poorly understood. Anterior cingulate (AC) cortex is one region characterized by considerable variability, particularly with respect to the paracingulate sulcus (PCS), which is present in only 30-60% of individuals and more commonly found in the left cerebral hemisphere. To investigate whether inter-individual differences in this PCS asymmetry are related to cognitive performance, we classified 30 healthy right-handed males as displaying either a leftward, rightward or symmetric pattern of folding based on the incidence and extent of the PCS in each hemisphere, and compared their performance on tasks engaging executive cognitive processes associated with frontal lobe function. We found that the more common leftward PCS asymmetry was associated with better performance across verbal and non-verbal executive tasks, but that PCS variability had no effect on tasks less dependent on executive functions. These results suggest that the leftward pattern of folding is associated with a non-specific performance advantage on cognitively demanding executive function tasks, possibly due to differences in functional interactions between AC/paracingulate cortex and connected frontal regions. It therefore appears that normal variations in brain morphology are associated with individual differences in cognitive abilities.