IMMUNOGLOBULIN-A IN PIG .1. PRELIMINARY CHARACTERIZATION OF NORMAL PIG SERUM IGA
IMMUNOGLOBULIN-A IN PIG .1. PRELIMINARY CHARACTERIZATION OF NORMAL PIG SERUM IGA
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DOI：
10.1159/000230312
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发表时间：
1970-01-01
期刊：
影响因子：
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通讯作者：
HEREMANS, JF
中科院分区：
文献类型：
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作者：
VAERMAN, JP;HEREMANS, JF
猪血清和牛奶中与人伊加同源的免疫球蛋白的发生已通过其与人伊加特异性兔抗血清的交叉反应得到证实。制备了一种抗猪伊加的特异性兔抗血清，用于追踪这种蛋白在DEAE-cellulose和Sephadex-G 200上层析以及在pH8.6的Pevikon上密度梯度超离心和电泳过程中的行为。猪血清伊加的理化性质，包括其在锌离子存在下的相对溶解度，强调了其与人伊加的相似性。然而，与人伊加不同，猪血清伊加的主要部分似乎由二聚体分子组成。
The occurrence in pig serum and milk of an immunoglobulin homologous to human IgA has been demonstrated by its cross-reaction with a rabbit antiserum specific for human IgA. A specific homo logous rabbit antiserum against pig IgA was prepared which was used to trace the behaviour of this protein during chromatography on DEAE-cellulose and Sephadex-G 200, as well as during density gradient ultracentrifugation and electrophoresis on Pevikon at pH 8.6. The physicochemical properties of pig serum IgA, including its relative solubility in the presence of zinc ions, emphasized its resemblance to human IgA. However, unlike human IgA, the major part of pig serum IgA seems to consist of dimer molecules.