Proton beam therapy is a safe and feasible treatment for patients with second primary lung cancer after lung resection.
Proton beam therapy is a safe and feasible treatment for patients with second primary lung cancer after lung resection.
复制标题
质子束治疗对于肺切除术后第二原发性肺癌患者是一种安全可行的治疗方法。
DOI：
10.1111/1759-7714.12949
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Nemoto K.
中科院分区：
文献类型：
--
作者：
Ono T;Nakamura T;Azami Y;Suzuki M;Wada H;Kikuchi Y;Murakami M;Nemoto K.
BackgroundThe purpose of the present study was to retrospective evaluate the safety and efficacy of proton beam therapy（PBT）in patients with second primary lung cancer after lung surgery.MethodsPatients who were diagnosed with second primary lung cancer after lung surgery and performed PBT between January 2009 and February 2015 were retrospectively recruitment.使用不良事件通用术语标准4.0版评价毒性。结果19例患者符合入选标准。所有患者均完成治疗。中位年龄为75岁（范围：63-82岁），存活患者的中位随访时间为60个月。PBT的中位剂量为76.8戈伊相对生物学有效性（范围：66.0-80.0戈伊）。3年总生存率为63.2%，3年局部控制率为84.2%。PBT.ConclusionsOur研究结果表明，与手术或X线放疗相比，PBT是一种安全可行的治疗第二原发性肺癌的方法。PBT可能成为肺切除术后第二原发肺癌患者的治疗选择。
BackgroundThe purpose of the present study was to retrospectively evaluate the safety and efficacy of proton beam therapy (PBT) in patients with second primary lung cancer after lung resection.MethodsPatients who were diagnosed with second primary lung cancer after lung resection and underwent PBT between January 2009 and February 2015 were retrospectively recruited. Toxicities were evaluated using Common Terminology Criteria for Adverse Events version 4.0.ResultsNineteen patients were eligible for inclusion in this study. All of the patients completed the treatment. The median age was 75 (range: 63–82) years, and the median follow‐up time of living patients was 60 months. The median dose of PBT was 76.8 Gy relative biological effectiveness (range: 66.0–80.0 Gy). The three‐year overall survival rate was 63.2% and the three‐year local control rate was 84.2%. No grade 4 or 5 toxicities were observed after PBT.ConclusionsOur results suggest that PBT is a safe and feasible treatment for second primary lung cancer compared to surgery or X‐ray radiotherapy. PBT may become a treatment choice for patients with second primary lung cancer after lung resection.