Comparative performance evaluation and systematic screening of solvents in a range of Grignard reactions
Comparative performance evaluation and systematic screening of solvents in a range of Grignard reactions
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DOI：
10.1039/c3gc40702k
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发表时间：
2013-01-01
期刊：
影响因子：
9.8
通讯作者：
Zhang, Wei
中科院分区：
文献类型：
--
作者：
Kadam, Asha;Mylinh Nguyen;Zhang, Wei
The solvent effect on the Grignard reaction of benzyl, aryl and heteroaromatic substrates has been systematically evaluated based on reaction efficiency, ease of subsequent work-up, safety and greenness. 2-Methyltetrahydrofuran (2-MeTHF), which can be derived from renewable resources, had at least an equal if not a superior overall process most notably in suppressing the Wurtz coupling by-product from the benzyl Grignard reactions. It is therefore a recommended alternative solvent to Et2O and THF for the preparation of most Grignard reagents and their subsequent reactions.
