Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept.
Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept.
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DOI：
10.1038/nn.4228
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发表时间：
2016-03
影响因子：
25
通讯作者：
Sullivan PF
中科院分区：
文献类型：
--
作者：
Franke B;Stein JL;Ripke S;Anttila V;Hibar DP;van Hulzen KJE;Arias-Vasquez A;Smoller JW;Nichols TE;Neale MC;McIntosh AM;Lee P;McMahon FJ;Meyer-Lindenberg A;Mattheisen M;Andreassen OA;Gruber O;Sachdev PS;Roiz-Santiañez R;Saykin AJ;Ehrlich S;Mather KA;Turner JA;Schwarz E;Thalamuthu A;Shugart YY;Ho YY;Martin NG;Wright MJ;Schizophrenia Working Group of the Psychiatric Genomics Consortium;ENIGMA Consortium;O'Donovan MC;Thompson PM;Neale BM;Medland SE;Sullivan PF
精神分裂症是一种遗传性很高的破坏性精神疾病。平均而言，精神分裂症患者和健康人的大脑结构和功能不同。由于精神分裂症和脑成像表型的共同遗传关联正在出现，我们现在可以使用全基因组数据来研究遗传重叠。在这里，我们综合了精神分裂症(33,636例，43,008名对照)和几个(主要是皮质下)大脑结构的体积(11,840名受试者)的常见变体研究的结果。我们没有发现精神分裂症风险和皮质下体积测量之间存在遗传重叠的证据，无论是在常见的变异遗传结构水平上，还是在单一遗传标记的水平上。目前的研究提供了概念验证(尽管基于一组有限的大脑结构测量)，并为未来研究结构/功能脑表型与精神疾病风险之间的遗传协方差确定了路线图。
Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, between schizophrenia cases and healthy individuals. As common genetic associations are emerging for both schizophrenia and brain imaging phenotypes, we can now use genome-wide data to investigate genetic overlap. Here we integrated results from common variant studies of schizophrenia (33,636 cases, 43,008 controls) and volumes of several (mainly subcortical) brain structures (11,840 subjects). We did not find evidence of genetic overlap between schizophrenia risk and subcortical volume measures either at the level of common variant genetic architecture or for single genetic markers. The current study provides proof-of-concept (albeit based on a limited set of structural brain measures), and defines a roadmap for future studies investigating the genetic covariance between structural/functional brain phenotypes and risk for psychiatric disorders.