Quantifying the strain history of bone: spatial uniformity and self-similarity of low-magnitude strains
Quantifying the strain history of bone: spatial uniformity and self-similarity of low-magnitude strains
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DOI：
10.1016/s0021-9290(99)00210-9
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发表时间：
2000-03-01
影响因子：
2.4
通讯作者：
Rubin, CT
中科院分区：
文献类型：
--
作者：
Fritton, SP;McLeod, KJ;Rubin, CT
我们假设，当一个广谱的骨应变被认为是，应变历史是相似的不同骨骼在不同的物种。使用具有精细分辨率的数据收集协议，在体内测量了三个物种（狗、羊）的承重和非承重骨的中段骨干应变。和火鸡，在动物进行自然日常活动时连续收集菌株信息。通过对循环应变事件计数（以量化不同量级的应变分布）和通过估计应变的平均频谱特性（以量化应变信号的频率含量）来量化每日应变历史。对每日（12-24小时）菌株事件的计数表明，大菌株（> 1000微菌株）每天发生相对较少的次数，而非常小的菌株（< 10微菌株）每天发生数千次。发现较低量级的应变（<类似于200微应变）：比较高量级的峰值应变在骨横截面周围更均匀。应变动力学被发现是很好地描述了幂律关系，并表现出自相似特性。这些数据表明，骨组织的组织是由跨越广泛但一致的频率和振幅范围的连续活动弹幕驱动的，并且直到完全理解骨骼机械感觉系统的机制，骨骼应变历史的所有部分都应被认为可能在骨骼适应中发挥作用。(C)2000爱思唯尔科技有限公司版权所有。
We hypothesize that when a broad spectrum of bone strain is considered, strain history is similar for different bones in different species. Using a data collection protocol with a fine resolution, mid-diaphyseal strains were measured in vivo for both weightbearing and non-weightbearing bones in three species: dog, sheep. and turkey, with strain information collected continuously while the animals performed their natural daily activities. The daily strain history was quantified by both counting cyclic strain events (to quantify the distribution of strains of different magnitudes) and by estimating the average spectral characteristics of the strain (to quantify the frequency content of the strain signals). Counting of the daily (12-24 h) strain events show that large strains ( > 1000 microstrain) occur relatively few times a day, while very small strains ( < 10 microstrain) occur thousands of times a day. The lower magnitude strains (< similar to 200 microstrain) are found to be: more uniform around the bone cross-section than the higher magnitude, peak strains. Strain dynamics are found to be well described by a power-law relationship and exhibit self-similar characteristics. These data lead to the suggestion that the organization of bone tissue is driven by the continual barrage of activity spanning a wide bur consistent range of frequency and amplitude, and until the mechanism of bones mechanosensory system is fully understood, all portions of bone's strain history should be considered to possibly play a role in bone adaptation. (C) 2000 Elsevier Science Ltd. All rights reserved.