Bcl-x L increases mitochondrial fission, fusion, and biomass in neurons.
Bcl-x L increases mitochondrial fission, fusion, and biomass in neurons.
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DOI：
10.1083/jcb.200809060
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发表时间：
2009-03-09
期刊：
影响因子：
--
通讯作者：
Hardwick JM
中科院分区：
文献类型：
--
作者：
Berman SB;Chen YB;Qi B;McCaffery JM;Rucker EB 3rd;Goebbels S;Nave KA;Arnold BA;Jonas EA;Pineda FJ;Hardwick JM
Mitochondrial fission and fusion are linked to synaptic activity in healthy neurons and are implicated in the regulation of apoptotic cell death in many cell types. We developed fluorescence microscopy and computational strategies to directly measure mitochondrial fission and fusion frequencies and their effects on mitochondrial morphology in cultured neurons. We found that the rate of fission exceeds the rate of fusion in healthy neuronal processes, and, therefore, the fission/fusion ratio alone is insufficient to explain mitochondrial morphology at steady state. This imbalance between fission and fusion is compensated by growth of mitochondrial organelles. Bcl-xL increases the rates of both fusion and fission, but more important for explaining the longer organelle morphology induced by Bcl-xL is its ability to increase mitochondrial biomass. Deficits in these Bcl-xL–dependent mechanisms may be critical in neuronal dysfunction during the earliest phases of neurodegeneration, long before commitment to cell death.
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DOI：
10.1073/pnas.0703976104
发表时间：
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影响因子：
11.1
作者：
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通讯作者：
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作者：
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通讯作者：
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DOI：
10.1083/jcb.200512079
发表时间：
2006-06-05
期刊：
The Journal of cell biology
影响因子：
--
作者：
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通讯作者：
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