Role of atrial natriuretic factor in volume control
Role of atrial natriuretic factor in volume control
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DOI：
10.1038/ki.1996.257
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发表时间：
1996-06-01
影响因子：
19.6
通讯作者：
Maack, T
中科院分区：
文献类型：
--
作者：
Maack, T
心房利钠因子（ANF）是一种由28个氨基酸组成的多肽类激素，主要由心房对心房牵张反应而分泌。ANF作用于肾脏，增加钠排泄和GFR，拮抗肾血管收缩，并抑制肾素分泌。在心血管系统中，ANF拮抗血管收缩，并将液体从血管内转移到间质室。在肾上腺中，ANF是一种强有力的醛固酮合成抑制剂。心钠素在急性和慢性容量超负荷的利钠反应中起重要作用。ANF将流体从血管转移到间质室的特性充当缓冲装置，防止在面对增加的总细胞外液体积时过度的血浆体积膨胀。ANF也是GFR的生理调节剂，并且当盐排泄受到肾单位数量减少的威胁时介导肾单位超滤和尿钠排泄。鸟苷酸环化酶（GC（A））受体通过产生cGMP介导ANF的作用。清除受体通过受体介导的内吞作用从循环中清除ANF，并作为激素缓冲系统阻止ANF血浆水平的大幅不适当波动。这些受体的特定结构-功能-动力学关系用于调节ANF在压力-容积稳态中的作用。
Atrial natriuretic factor (ANF) is a 28 amino acid polypeptide hormone secreted mainly by the heart atria in response to atrial stretch. ANF acts on the kidney to increase sodium excretion and GFR, to antagonize renal vasoconstriction, and to inhibit renin secretion. In the cardiovascular system, ANF antagonizes vasoconstriction, and shifts fluid from the intravascular to the interstitial compartment. In the adrenal gland, ANF is a powerful inhibitor of aldosterone synthesis. ANF participates importantly in the natriuretic response to acute and chronic volume overload. ANF's property of shifting fluid from the vascular to the interstitial compartment acts as a buffering device, guarding against excessive plasma volume expansion in face of an increased total extracellular fluid volume. ANF is also a physiological modulator of GFR, and mediates nephron hyperfiltration and natriuresis when salt excretion is threatened by a reduction in the number of nephrons. Guanylyl cyclase (GC(A)) receptors mediate the effects of ANF by generating cGMP. Clearance receptors remove ANF from the circulation by receptor-mediated endocytosis, and serve as a hormone buffer system to impede large inappropriate fluctuations in plasma levels of ANF. The specific structure-function-dynamics relationships of these receptors serve to modulate the role of ANF in pressure-volume homeostasis.