Encapsulating Peritoneal Sclerosis Associated with Abnormal Liver Development in a Young Dog
Encapsulating Peritoneal Sclerosis Associated with Abnormal Liver Development in a Young Dog
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DOI：
10.1292/jvms.10-0503
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发表时间：
2011-05-01
影响因子：
1.2
通讯作者：
Kuwamura, Mitsuru
中科院分区：
文献类型：
--
作者：
Izawa, Takeshi;Murai, Fumi;Kuwamura, Mitsuru
一只6个月大的雄性小型杜宾犬出现慢性腹水，腹部器官形成纤维膜，肠袢之间存在大量粘连。两次手术切除膜和粘连，但狗在初次就诊后 1 个月死亡。尸检发现膜和肠粘连复发。纤维膜由较厚的成熟胶原结缔组织组成，其上覆盖未成熟的胶原结缔组织，有轻度淋巴浆细胞浸润，新生血管明显，纤维蛋白渗出。在肝、脾、胃和肠的浆膜中也观察到类似的纤维化病变。这些发现与人类和狗报道的包裹性腹膜纤维化一致。该狗的肝脏也发育不良，其特点是肝小叶紊乱和肝索紊乱。
A 6-month-old male miniature pinscher dog developed chronic ascites, formation of fibrous membrane covering the abdominal organs, and numerous adhesions between the intestinal loops. The membrane and adhesions were surgically removed twice, but the dog died 1 month after initial presentation. Necropsy revealed recurrence of the membrane and intestinal adhesions. The fibrous membrane was composed of a thick layer of mature collagenous connective tissue, covered by immature collagenous connective tissue with mild lymphoplasmacytic infiltration, prominent neovascularization, and fibrin exudation. Similar fibrotic lesions were observed in the serosa of the liver, spleen, stomach and intestines. These findings are consistent with encapsulating peritoneal fibrosis reported in humans and dogs. The dog also had a maldeveloped liver, which is characterized by disorganized hepatic lobules and disarranged hepatic cords.