Quantitative in vivo assessment of lung microstructure at the alveolar level with hyperpolarized 3He diffusion MRI
Quantitative in vivo assessment of lung microstructure at the alveolar level with hyperpolarized 3He diffusion MRI
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DOI：
10.1073/pnas.052594699
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发表时间：
2002-03-05
影响因子：
11.1
通讯作者：
Conradi, MS
中科院分区：
文献类型：
--
作者：
Yablonskiy, DA;Sukstanskii, AL;Conradi, MS
对肺气肿的研究可以追溯到17世纪初。然而，许多重要问题仍未得到解答，因为肺气肿的定量局部特征需要了解完整活肺中肺泡水平的肺结构。传统成像方式和肺功能测试无法提供此信息。在此，我们报告了在健康人类受试者和严重肺气肿患者中使用 He-3 扩散 MRI 获得的肺泡水平肺几何参数的首次体内测量结果。我们还提供了第一个实验数据，证明 3He 气体在人肺腺泡中的扩散率是高度各向异性的。提出了各向异性扩散理论。我们的结果清楚地表明健康肺和肺气肿肺在腺泡水平上存在显着差异，并可能为肺气肿进展提供新的见解。该技术有望成为肺气肿早期诊断的临床工具。
The study of lung emphysema dates back to the beginning of the 17th century. Nevertheless, a number of important questions remain unanswered because a quantitative localized characterization of emphysema requires knowledge of lung structure at the alveolar level in the intact living lung. This information is not available from traditional imaging modalities and pulmonary function tests. Herein, we report the first in vivo measurements of lung geometrical parameters at the alveolar level obtained with He-3 diffusion MRI in healthy human subjects and patients with severe emphysema. We also provide the first experimental data demonstrating that 3He gas diffusivity in the acinus of human lung is highly anisotropic. A theory of anisotropic diffusion is presented. our results clearly demonstrate substantial differences between healthy and emphysematous lung at the acinar level and may provide new insights into emphysema progression. The technique offers promise as a clinical tool for early diagnosis of emphysema.