Relationship of Hypertension and Systolic Blood Pressure With the Risk of Stroke or Bleeding in Patients With Atrial Fibrillation: The Fushimi AF Registry
Relationship of Hypertension and Systolic Blood Pressure With the Risk of Stroke or Bleeding in Patients With Atrial Fibrillation: The Fushimi AF Registry
复制标题
DOI：
10.1093/ajh/hpx094
复制
发表时间：
2017-11-01
影响因子：
3.2
通讯作者：
Akao, Masaharu
中科院分区：
文献类型：
--
作者：
Ishii, Mitsuru;Ogawa, Hisashi;Akao, Masaharu
背景高血压被认为是中风和全身性栓塞（SE）以及房颤（AF）患者出血的主要危险因素。本研究的目的是调查高血压和收缩压（SBP）与中风/SE或出血的风险在AF patients. METHODS伏见AF登记，以社区为基础的前瞻性调查，旨在招募所有的AF患者在伏见区，京都的关系。伏见区人口稠密，总人口为283，000人。有3,713名患者的随访数据可用截至2015年8月，随访率为90.0%，中位随访期为1，035天。我们比较了高血压患者（HTN; n = 2，304，占总数的62.1%）和非高血压患者（非HTN; n = 1，409）的基线临床背景和AF患者的随访结果。高血压病史与卒中/SE、缺血性卒中、出血性卒中或大出血的发生率无关。然而，当我们按照基线SBP = 150 mm Hg（HTN-高血压[HBP]：n = 305，HTN组的13.3%）或
BACKGROUNDHypertension is considered a major risk factor of stroke and systemic embolism (SE) as well as bleeding in patients with atrial fibrillation (AF). The purpose of this study was to investigate the relationship of hypertension and systolic blood pressure (SBP) with the risk of stroke/SE or bleeding in AF patients.METHODSThe Fushimi AF Registry, a community-based prospective survey, was designed to enroll all of the AF patients in Fushimi-ku, Kyoto. Fushimi-ku is densely populated with a total population of 283,000. Follow-up data were available for 3,713 patients (follow-up rate 90.0%) as of August 2015, and the median follow-up period was 1,035 days.RESULTSWe compared the clinical backgrounds at baseline, and follow-up outcomes of AF patients between those with hypertension (HTN; n = 2,304, 62.1% of total) and those without (non-HTN; n = 1,409). History of hypertension was neither associated with the incidence of stroke/SE, ischemic stroke, hemorrhagic stroke nor major bleeding. However, when we divided the HTN group by baseline SBP = 150 mm Hg (HTN-high blood pressure [HBP]: n = 305, 13.3% of HTN group) or