Nuclear factor-kappaB and tumor-associated macrophages.
Nuclear factor-kappaB and tumor-associated macrophages.
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核因子 - 卡帕布和肿瘤相关的巨噬细胞。
DOI：
10.1158/1078-0432.ccr-09-1015
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发表时间：
2010-02-01
期刊：
影响因子：
--
通讯作者：
Lawrence T
中科院分区：
文献类型：
--
作者：
Mancino A;Lawrence T
肿瘤相关巨噬细胞（TAM）通过促进肿瘤血管生成、生长和转移与癌症进展相关。人们对维持 TAM 促肿瘤表型的精确机制知之甚少，但最近的研究强调了许多对 TAM 表型和功能很重要的信号通路。核因子-κB (NF-κB) 被认为是炎症和免疫反应的主要调节因子。最近的一些遗传学研究表明，NF-κB 是 TAM 中整合肿瘤微环境信号促进癌变的重要途径。本综述将重点关注 NF-κB 在 TAM 中的作用以及针对该通路作为新型癌症治疗策略的潜力。
Tumor-associated macrophages (TAM) have been linked with progression of cancer by favoring tumor angiogenesis, growth and metastasis. The precise mechanisms that maintain the pro-tumor phenotype of TAM are poorly understood, but recent research has highlighted a number of signaling pathways that are important in TAM phenotype and function. Nuclear Factor-κB (NF-κB) is considered the master regulator of inflammatory and immune responses. Recently several genetic studies have indicated NF-κB is an important pathway in TAM for the integration of signals from tumor microenvironment that promote carcinogenesis. This review will focus on the role of NF-κB in TAM and the potential of targeting this pathway as novel therapeutic strategy against cancer.