Coarse electrocorticographic decoding of ipsilateral reach in patients with brain lesions.
Coarse electrocorticographic decoding of ipsilateral reach in patients with brain lesions.
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DOI：
10.1371/journal.pone.0115236
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Crone NE
中科院分区：
文献类型：
--
作者：
Hotson G;Fifer MS;Acharya S;Benz HL;Anderson WS;Thakor NV;Crone NE
对于因中风和其他脑部病变而导致单侧上肢瘫痪的患者，功能恢复的策略可能最终包括使用来自受损半球残余感觉运动系统的控制信号的脑机接口（bmi）。当对侧肢体由于脑部病理不能自主运动时，这种BMI的初始训练可能需要使用未受影响的同侧肢体。我们对三名患有与上肢控制相关的感觉运动系统不同病变的患者进行了一项离线调查，研究了从皮质电图（ECoG）记录中解码同侧上肢运动的可行性。我们发现，第一主成分（PC）的无约束，上肢的自然到达运动可以解码从同侧ECoG使用线性模型。产生最佳解码精度的ECoG信号特征在受试者之间是不同的。输入特征很少，性能饱和。解码性能分别为0.77、0.73和0.66（使用9个信号特征的预测和实际第一次运动PC之间的Pearson's r中值）。通过少量电极和计算简单的解码算法实现的性能表明，使用受损感觉运动脑系统记录的ECoG来控制BMI是可能的。
In patients with unilateral upper limb paralysis from strokes and other brain lesions, strategies for functional recovery may eventually include brain-machine interfaces (BMIs) using control signals from residual sensorimotor systems in the damaged hemisphere. When voluntary movements of the contralateral limb are not possible due to brain pathology, initial training of such a BMI may require use of the unaffected ipsilateral limb. We conducted an offline investigation of the feasibility of decoding ipsilateral upper limb movements from electrocorticographic (ECoG) recordings in three patients with different lesions of sensorimotor systems associated with upper limb control. We found that the first principal component (PC) of unconstrained, naturalistic reaching movements of the upper limb could be decoded from ipsilateral ECoG using a linear model. ECoG signal features yielding the best decoding accuracy were different across subjects. Performance saturated with very few input features. Decoding performances of 0.77, 0.73, and 0.66 (median Pearson's r between the predicted and actual first PC of movement using nine signal features) were achieved in the three subjects. The performance achieved here with small numbers of electrodes and computationally simple decoding algorithms suggests that it may be possible to control a BMI using ECoG recorded from damaged sensorimotor brain systems.
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影响因子：
4
作者：
McFarland DJ;Sarnacki WA;Wolpaw JR
通讯作者：
Wolpaw JR
影响因子：
4
作者：
Kubánek J;Miller KJ;Ojemann JG;Wolpaw JR;Schalk G
通讯作者：
Schalk G
DOI：
10.1016/s0003-9993(96)90262-2
发表时间：
1996-08-01
影响因子：
4.3
作者：
Hanlon, RE
通讯作者：
Hanlon, RE
影响因子：
9.9
作者：
LEVINE, DN;KAUFMAN, KJ;MOHR, JP
通讯作者：
MOHR, JP
影响因子：
4
作者：
Acharya S;Fifer MS;Benz HL;Crone NE;Thakor NV
通讯作者：
Thakor NV