Normal liver tissue change after proton beam therapy
Normal liver tissue change after proton beam therapy
复制标题
质子束治疗后正常肝组织的变化
DOI：
10.1007/s11604-018-0757-9
复制
发表时间：
2018
期刊：
影响因子：
2.1
通讯作者：
Sakurai H
中科院分区：
文献类型：
--
作者：
Fukumitsu N;Takahashi S;Okumura T;Ishida T;Murofushi KN;Ohnishi K;Aihara T;Ishikawa H;Tsuboi K;Sakurai H
目的调查质子束治疗 (PBT) 治疗后 1 年和 2 年患者的正常肝组织变化。材料和方法检查正常肝组织体积的变化。随访CT上也模拟了正常肝组织的剂量分布。结果治疗前正常肝组织体积为1149±215 cm3，治疗1年为1089±188 cm3，治疗后2年为1080±236 cm3。 2年时正常肝组织体积增加10例，减少20例，总体积较治疗前减少（P= 0.03）。接受超过30格雷当量[V30(cm3)]治疗1年时的模拟体积为258± 187 cm3，2年时的模拟体积(244± 171 cm3)较治疗前(297± 140 cm3)小(P= 0.03)。结论正常肝脏组织并不是恒定的，这导致正常肝脏在2年内存在较大的剂量分布差异。因此，在计划再次照射时需要仔细考虑正常肝组织的剂量分布。
PurposeNormal liver tissue changes after proton beam therapy (PBT) were investigated in patients at 1 and 2 years after the therapy.Materials and methodsChanges in normal liver tissue volume were examined. The dose distribution of the normal liver tissue was also simulated on the follow-up CTs.ResultsThe normal liver tissue volume was 1149 ± 215 cm3before treatment, 1089 ± 188 cm3at 1 year, and 1080 ± 236 cm3at 2 years after treatment. The normal liver tissue volume was increased in 10 and decreased in 20 patients at 2 years and was smaller than that before the treatment in total (P= 0.03). The simulated volume that received more than 30 Gray equivalent [V30 (cm3)] at 1 year was 258 ± 187 cm3and that at 2 years (244 ± 171 cm3) was smaller than that before treatment (297 ± 140 cm3) (P= 0.03).ConclusionsThe changes in the shape and volume of normal liver tissue are not constant, which cause a large dose distribution discrepancy in the normal liver for 2 years. Therefore, careful consideration of the dose distribution of normal liver tissue is required when planning re-irradiation.