Granulomatous prostatitis and poorly differentiated prostate carcinoma. Their distinction with the use of immunohistochemical methods.
Granulomatous prostatitis and poorly differentiated prostate carcinoma. Their distinction with the use of immunohistochemical methods.
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肉芽肿性前列腺炎和低分化前列腺癌。
DOI：
10.1093/ajcp/95.3.330
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发表时间：
1991
影响因子：
3.5
通讯作者：
N. Weidner
中科院分区：
文献类型：
--
作者：
B. Presti;N. Weidner
肉芽肿性前列腺炎和低分化前列腺癌在临床和组织学上可以相互模仿。为了制定有助于解决问题病例的标准，作者将这些病症（九例肉芽肿性前列腺炎和六例低分化癌）与一组细胞角蛋白（AE1/3）、前列腺特异性抗原（PSA）、前列腺酸性磷酸酶（PAP）、溶菌酶、抗巨噬细胞M和白细胞共同抗原（LCA）抗体的反应性进行了比较。在肉芽肿性前列腺炎中，组织细胞对 PAP、PSA 或细胞角蛋白没有免疫反应；然而，9 例中有 9 例组织细胞对溶菌酶产生反应，9 例中有 7 例对抗巨噬细胞 M 产生反应，9 例中有 1 例对 LCA 产生反应。所有六例癌症病例的肿瘤细胞均与 PAP、PSA 和细胞角蛋白发生反应；所有这些都未能与溶菌酶、LCA 和抗巨噬细胞 M 发生反应。作者得出的结论是，肉芽肿性前列腺炎和低分化癌可以通过免疫组织化学方法可靠地区分。
Granulomatous prostatitis and poorly differentiated prostate carcinoma can mimic each other both clinically and histologically. To develop criteria useful in resolving problem cases, the authors compared the reactivities of these conditions (nine cases of granulomatous prostatitis and six cases of poorly differentiated carcinoma) with a panel of antibodies to cytokeratin (AE1/3), prostate-specific antigen (PSA), prostatic acid phosphatase (PAP), lysozyme, antimacrophage M, and leukocyte common antigen (LCA). In granulomatous prostatitis, histiocytes were not immunoreactive for PAP, PSA, or cytokeratin; however, histiocytes reacted to lysozyme in nine of nine cases, antimacrophage M in seven of nine cases, and LCA in one of nine cases. Tumor cells from all six carcinoma cases reacted with PAP, PSA, and cytokeratin; all failed to react with lysozyme, LCA, and antimacrophage M. The authors conclude that granulomatous prostatitis and poorly differentiated carcinoma can be reliably distinguished with immunohistochemical methods.