Exaggerated phase-amplitude coupling in the primary motor cortex in Parkinson disease
Exaggerated phase-amplitude coupling in the primary motor cortex in Parkinson disease
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DOI：
10.1073/pnas.1214546110
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发表时间：
2013-03-19
影响因子：
11.1
通讯作者：
Starr, Philip A.
中科院分区：
文献类型：
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作者：
de Hemptinne, Coralie;Ryapolova-Webb, Elena S.;Starr, Philip A.
皮层区域之间大规模相互作用的一个重要机制涉及不同脑节律的相位和振幅之间的耦合。基底神经节疾病会破坏这种机制吗？我们通过分析接受神经外科手术的患者的初级运动皮层（M1）臂区记录的局部场电位来回答这个问题。在帕金森病中，与颅颈肌张力障碍患者和无运动障碍的人相比，M1中β相（13-30 Hz）和γ振幅（50-200 Hz）之间的耦合被夸大。过度耦合可通过治疗性丘脑底核刺激来减少。M1伽马振幅的峰值与丘脑底核β谷耦合，并先于丘脑底核β谷。结果提示模型的基底神经节皮层电路在帕金森病合并相位-振幅相互作用和异常的皮质丘脑底反馈，并建议M1局部场电位可以用作控制信号的基底神经节刺激器的自动编程。
An important mechanism for large-scale interactions between cortical areas involves coupling between the phase and the amplitude of different brain rhythms. Could basal ganglia disease disrupt this mechanism? We answered this question by analysis of local field potentials recorded from the primary motor cortex (M1) arm area in patients undergoing neurosurgery. In Parkinson disease, coupling between beta-phase (13-30 Hz) and gamma-amplitude (50-200 Hz) in M1 is exaggerated compared with patients with craniocervical dystonia and humans without a movement disorder. Excessive coupling may be reduced by therapeutic subthalamic nucleus stimulation. Peaks in M1 gamma-amplitude are coupled to, and precede, the subthalamic nucleus beta-trough. The results prompt a model of the basal ganglia-cortical circuit in Parkinson disease incorporating phase-amplitude interactions and abnormal corticosubthalamic feedback and suggest that M1 local field potentials could be used as a control signal for automated programming of basal ganglia stimulators.