Sensory cortical ensembles exhibit differential coupling to ripples in distinct hippocampal subregions.
Sensory cortical ensembles exhibit differential coupling to ripples in distinct hippocampal subregions.
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感觉皮层整体表现出与不同海马亚区域波纹的差异耦合。
DOI：
10.1101/2023.03.17.533028
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Andermann,MarkL
中科院分区：
文献类型：
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作者：
Jeong,Huijeong;Namboodiri,VijayMohanK;Jung,MinWhan;Andermann,MarkL
在最近的经历中激活的皮质神经元通常会在随后的休息期间随着背侧海马 CA1 波纹重新激活。关于皮质与中间海马 CA1 的相互作用知之甚少，其连接性、功能和波纹事件与背侧 CA1 不同。我们在小鼠视觉皮层中发现了三组假定的兴奋性神经元，它们优先与背侧或中间 CA1 波纹一起兴奋，或在两个波纹之前被抑制。每个簇中的神经元均匀分布在初级和高级视觉皮层中，即使在没有波纹的情况下也能协同活动。这些整体表现出相似的视觉反应，但与丘脑和瞳孔指数唤醒的耦合不同。我们观察到在波动之前和预测波动的一致活动序列：（1）抑制波动抑制的皮质神经元，（2）丘脑沉默，以及（3）中间CA1波动激活的皮质神经元的激活。我们提出，这些整体的协调动力学将视觉体验传递到不同的海马亚区域，以纳入不同的认知地图。
Cortical neurons activated during recent experiences often reactivate with dorsal hippocampal CA1 ripples during subsequent rest. Less is known about cortical interactions with intermediate hippocampal CA1, whose connectivity, functions, and ripple events differ from dorsal CA1. We identified three clusters of putative excitatory neurons in mouse visual cortex that are preferentially excited together with either dorsal or intermediate CA1 ripples or suppressed before both ripples. Neurons in each cluster were evenly distributed across primary and higher visual cortices and co-active even in the absence of ripples. These ensembles exhibited similar visual responses but different coupling to thalamus and pupil-indexed arousal. We observed a consistent activity sequence preceding and predicting ripples: (1) suppression of ripple-suppressed cortical neurons, (2) thalamic silence, and (3) activation of intermediate CA1-ripple-activated cortical neurons. We propose that coordinated dynamics of these ensembles relay visual experiences to distinct hippocampal subregions for incorporation into different cognitive maps.