The importance of non-transferrin bound iron in disorders of iron metabolism
The importance of non-transferrin bound iron in disorders of iron metabolism
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DOI：
10.1016/s0955-3886(00)00087-4
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发表时间：
2000-12-01
期刊：
影响因子：
--
通讯作者：
Cabantchik, ZI
中科院分区：
文献类型：
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作者：
Breuer, W;Hershko, C;Cabantchik, ZI
非转铁蛋白结合铁（NTBI）的概念是在22年前由Hershko等人提出的。[j] .中华医学杂志。40（1978）。它源于一种怀疑，即在铁超载的患者中，释放到循环中的大量过量铁可能超过血清转铁蛋白（Tf）铁结合能力（TIBC），导致出现各种形式的铁不与Tf结合。根据这一假设，NTBI最初是在大于或等于100% tf饱和度的患者中寻找和检测到的。随着其检测技术变得更加复杂和敏感，在Tf不完全饱和的条件下也发现了NTBI，这导致了对NTBI作为简单溢出现象的原始观点的修正。在这篇综述中，我们将讨论NTBI的一些特性，它的检测方法，它的意义和潜在价值作为铁螯合和补充治疗方案的指标。(C) 2000 Elsevier Science Ltd.版权所有。
The concept of non-transferrin bound iron (NTBI) was introduced 22 years ago by Hershko et al. (Brit. J. Haematol. 40 (1978) 255). It stemmed from a suspicion that, in iron overloaded patients, the large amounts of excess iron released into the circulation are likely to exceed the serum transferrin (Tf) iron-binding capacity (TIBC), leading to the appearance of various forms of iron not bound to Tf. In accordance with this assumption, NTBI was initially looked for and detected in patients with greater than or equal to 100% Tf-saturation. As techniques for its detection became more sophisticated and sensitive, NTBI was also found in conditions where Tf was not fully saturated, leading to a revision of the original view of NTBI as a simple spillover phenomenon. In this review, we will discuss some of the properties of NTBI, methods for its detection, its significance and potential value as an indicator for therapeutic regimens of iron chelation and supplementation. (C) 2000 Elsevier Science Ltd. All rights reserved.