Micro- and nanotechnology in cell separation.
Micro- and nanotechnology in cell separation.
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细胞分离中的微技术和纳米技术。
DOI：
10.2147/nano.2006.1.1.3
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发表时间：
2006
影响因子：
8
通讯作者：
中科院分区：
文献类型：
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作者：
这篇综述描述了使用微米和纳米技术分离细胞的最新工作。与传统的大规模分离系统相比，这些设备在样品量、低成本、便携性以及与其他分析技术集成的潜力方面具有几个优势。更重要的是，在现代医学的背景下，这些技术为即时诊断、药物发现和化学或生物制剂检测提供了工具。本文综述了基于(1)大小、(2)磁吸引、(3)荧光、(4)表面黏附和(5)新的新兴技术的五大类细胞分离的工作。每一类中的例子都是为了说明分离原则和技术解决办法以及这一迅速崛起的领域所面临的挑战。
This review describes recent work in cell separation using micro- and nanoscale technologies. These devices offer several advantages over conventional, macroscale separation systems in terms of sample volumes, low cost, portability, and potential for integration with other analytical techniques. More importantly, and in the context of modern medicine, these technologies provide tools for point-of-care diagnostics, drug discovery, and chemical or biological agent detection. This review describes work in five broad categories of cell separation based on (1) size, (2) magnetic attraction, (3) fluorescence, (4) adhesion to surfaces, and (5) new emerging technologies. The examples in each category were selected to illustrate separation principles and technical solutions as well as challenges facing this rapidly emerging field.