Simultaneous recording of MEG, EEG and intracerebral EEG during visual stimulation: From feasibility to single-trial analysis
Simultaneous recording of MEG, EEG and intracerebral EEG during visual stimulation: From feasibility to single-trial analysis
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DOI：
10.1016/j.neuroimage.2014.05.055
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发表时间：
2014-10-01
期刊：
影响因子：
5.7
通讯作者：
Benar, Christian-G.
中科院分区：
文献类型：
--
作者：
Dubarry, Anne-Sophie;Badier, Jean-Michel;Benar, Christian-G.
脑电图（EEG）、脑磁图（MEG）和脑内立体定向脑电图（SEEG）是三种神经生理记录技术，被认为可以捕捉到相同类型的大脑活动。尽管如此，非侵入性（EEG， MEG）和侵入性（SEEG）信号之间的关系仍有待进一步研究。在早期尝试将SEEG与EEG或MEG进行比较时，对每种模式分别进行记录。然而，这种方法在信号分析方面存在很大的局限性。本技术笔记的目的是探讨同时记录这三种信号模式（EEG， MEG和SEEG）的可行性，并提供分析这种新数据的策略。在顽固性癫痫患者中植入脑内电极以进行术前评估。本例患者采用视觉刺激模式，同时记录三种类型的信号。分析开始于对由SEEG设备引起的MEG伪影的表征。接下来，在传感器水平上计算平均诱发活动，并估计脑电和脑磁图记录的皮质源激活；这些被证明与SEEG信号的时空动态是兼容的。在平均时频域中，在40 Hz以下，MEG/EEG和SEEG记录之间的模式一致。最后，在单一诱发反应的水平上，在时域中检测到三种记录模式的振幅之间的细粒度耦合。重要的是，这些相关性显示出高度的空间和时间特异性。这些发现为三峰记录（EEG， MEG和SEEG）在研究大脑信号和功能方面达到更高水平的特异性提供了一个案例。(C) 2014爱思唯尔公司版权所有。
Electroencephalography (EEG), magnetoencephalography (MEG), and intracerebral stereotaxic EEG (SEEG) are the three neurophysiological recording techniques, which are thought to capture the same type of brain activity. Still, the relationships between non-invasive (EEG, MEG) and invasive (SEEG) signals remain to be further investigated. In early attempts at comparing SEEG with either EEG or MEG, the recordings were performed separately for each modality. However such an approach presents substantial limitations in terms of signal analysis. The goal of this technical note is to investigate the feasibility of simultaneously recording these three signal modalities (EEG, MEG and SEEG), and to provide strategies for analyzing this new kind of data. Intracerebral electrodes were implanted in a patient with intractable epilepsy for presurgical evaluation purposes. This patient was presented with a visual stimulation paradigm while the three types of signals were simultaneously recorded. The analysis started with a characterization of the MEG artifact caused by the SEEG equipment. Next, the average evoked activities were computed at the sensor level, and cortical source activations were estimated for both the EEG and MEG recordings; these were shown to be compatible with the spatiotemporal dynamics of the SEEG signals. In the average time-frequency domain, concordant patterns between the MEG/EEG and SEEG recordings were found below the 40 Hz level. Finally, a fine-grained coupling between the amplitudes of the three recording modalities was detected in the time domain, at the level of single evoked responses. Importantly, these correlations have shown a high level of spatial and temporal specificity. These findings provide a case for the ability of trimodal recordings (EEG, MEG, and SEEG) to reach a greater level of specificity in the investigation of brain signals and functions. (C) 2014 Elsevier Inc. All rights reserved.