Aspects on tubular proteinuria.
Aspects on tubular proteinuria.
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关于管状蛋白尿的方面。
DOI：
10.3109/03009738509178632
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发表时间：
1985
影响因子：
3.4
通讯作者：
L. Wibell
中科院分区：
文献类型：
--
作者：
L. Wibell
肾小管性蛋白尿，或低分子量(LMW)蛋白尿，较肾小球蛋白尿少见，但通常具有临床意义。现在临床常规实验室通常可以通过电泳法对尿蛋白图谱进行定性分析，并对各种低分子量蛋白进行定量评估。因此，可以寻找低分子量蛋白尿，作为近端肾小管功能受损的迹象。为此，可将β2-微球蛋白作为标记蛋白。慢性镉中毒和巴尔干肾病是通过使用低分子蛋白质测定进行广泛研究的情况的例子。在这方面，一些罕见的遗传性疾病也值得特别提及。药物或其他药物对肾脏的毒性损伤通常会在病程早期影响肾小管，并可通过LMW-蛋白质分析进行识别。此外，在其他临床情况下，尿液中的低分子量蛋白可用于调查或研究目的。
Tubular proteinuria, or low molecular weight (LMW) proteinuria, is less common than glomerular proteinuria, but is often of clinical significance. Both qualitative analysis of the urinary protein pattern by electrophoresis and quantitative estimations of various LMW-proteins are now usually available in the clinical routine laboratories. It is thus possible to look for LMW-proteinuria, as a sign of damage to the function of proximal renal tubules. For this purpose beta 2-microglobulin may be used as marker protein. Chronic cadmium poisoning and the Balkan nephropathy are examples of conditions which have been extensively studied by the use of LMW-protein determinations. In this context also some rare hereditary disorders deserve to be specially mentioned. Toxic injury to the kidneys, by drugs or other agents, often affect the kidney tubules early in the course and may be identified by LMW-protein analysis. Also in other clinical situations LMW-proteins in the urine may be used for investigative or research purposes.