Gene regulation by non-coding RNAs.
Gene regulation by non-coding RNAs.
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DOI：
10.3109/10409238.2013.844092
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发表时间：
2014-01
影响因子：
6.5
通讯作者：
Rana TM
中科院分区：
文献类型：
--
作者：
Patil VS;Zhou R;Rana TM
在过去的二十年里，非编码RNA及其生理和病理功能的研究出现了爆炸式增长。几类小的（20-30个核苷酸）和长的（>200个核苷酸）非编码RNA已经被牢固地确立为从胚胎发育到先天免疫的无数过程中基因表达的关键调节因子。在这篇综述中，我们专注于我们目前的理解的生物起源和功能的小干扰RNA（siRNA），microRNA（miRNA），和Piwi相互作用的RNA（piRNA）的分子机制。此外，我们简要地回顾了小的和长的非编码RNA的相关性，人类的生理和病理学和它们的潜力被开发为治疗剂。
The past two decades have seen an explosion in research on noncoding RNAs and their physiological and pathological functions. Several classes of small (20–30 nucleotides) and long (>200 nucleotides) noncoding RNAs have been firmly established as key regulators of gene expression in myriad processes ranging from embryonic development to innate immunity. In this review, we focus on our current understanding of the molecular mechanisms underlying the biogenesis and function of small interfering RNAs (siRNAs), microRNAs (miRNAs), and Piwi-interacting RNAs (piRNAs). In addition, we briefly review the relevance of small and long noncoding RNAs to human physiology and pathology and their potential to be exploited as therapeutic agents.