Ganoderic acid DM: Anti-androgenic osteoclastogenesis inhibitor
Ganoderic acid DM: Anti-androgenic osteoclastogenesis inhibitor
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DOI：
10.1016/j.bmcl.2009.02.119
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发表时间：
2009-04-15
影响因子：
2.7
通讯作者：
Kondo, Ryuichiro
中科院分区：
文献类型：
--
作者：
Liu, Jie;Shiono, Jun;Kondo, Ryuichiro
前列腺癌是西方国家男性最常见的癌症，骨转移发生率高。从灵芝乙醇提取物中分离得到的灵芝酸DM具有抑制5 α -还原酶和雄激素受体（AR）结合活性，能抑制前列腺癌细胞生长，阻断破骨细胞发生。2009爱思唯尔有限公司版权所有。
Prostate cancer is the most common cancer in men in Western countries, with a high incidence of bone metastasis. Ganoderic acid DM, with 5 alpha-reductase inhibitory and androgen receptor (AR) binding activity, isolated from the ethanol extracts of Ganoderma lucidum, can inhibit prostate cancer cell growth and block osteoclastogenesis. (C) 2009 Elsevier Ltd. All rights reserved.