Association of the dysbindin gene with bipolar affective disorder
Association of the dysbindin gene with bipolar affective disorder
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DOI：
10.1176/appi.ajp.163.9.1636
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发表时间：
2006-09-01
影响因子：
17.7
通讯作者：
Collier, David
中科院分区：
文献类型：
--
作者：
Breen, Gerome;Prata, Diana;Collier, David
目的：在双相情感障碍和精神分裂症的研究中，有一些证据表明这两种疾病之间存在表型和遗传重叠。然而，双相情感障碍和精神分裂症之间的可能联系仍然是不确定的。作者假设，dysbindin，这是一个可能的易感基因，精神分裂症，与双相情感disorder.Method的病例对照设计study.Participants包括213例双相I型精神障碍和197名对照科目，并验证了这一假设。在每一个主题中，10个dysbindin基因多态性进行了基因分型和assessed.Results：两个多态性显示个人基因型与双相I障碍。多个标记单倍型更强的相关性，与罕见的两个常见的单倍型在双相情感障碍患者中被过度代表。一个类似的发现在精神分裂症患者在以前的study.Conclusions：研究结果表明，人类dysbindin基因可能发挥作用的易感性双相情感障碍，这强调了一个潜在的重要领域的病因重叠与精神分裂症。共同的遗传风险因素的存在，最终将导致目前主要精神病疾病分类的变化。
Objective: In the study of bipolar affective disorder and schizophrenia, there is some evidence suggesting a phenotypic and genetic overlap between the two disorders. A possible link between bipolar affective disorder and schizophrenia remains arguable, however. The authors hypothesized that dysbindin, which is a probable susceptibility gene for schizophrenia, was associated with bipolar affective disorder and tested this hypothesis using a case- control design study.Method: Participants included 213 patients with bipolar I disorder and 197 comparison subjects. In each subject, 10 polymorphisms in the dysbindin gene were genotyped and assessed.Results: Two polymorphisms showed individual genotypic association with bipolar I disorder. Multiple marker haplotypes were more strongly associated, with the rarer of the two common haplotypes being overrepresented in the patients with bipolar affective disorder. A similar finding was reported in patients with schizophrenia in a previous study.Conclusions: Findings suggest that the human dysbindin gene may play a role in the susceptibility to bipolar affective disorder, which underscores a potentially important area of etiological overlap with schizophrenia. The existence of shared genetic risk factors will, in time, lead to changes in the current nosology of major psychoses.