Spike transmission and synchrony detection in networks of GABAergic interneurons
Spike transmission and synchrony detection in networks of GABAergic interneurons
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DOI：
10.1126/science.1061395
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发表时间：
2001-06-22
期刊：
影响因子：
56.9
通讯作者：
Hestrin, S
中科院分区：
文献类型：
--
作者：
Galarreta, M;Hestrin, S
新皮质神经元之间动作电位的时间模式和相对时机可能携带重要信息。但是，皮质回路如何检测或产生相干活性尚不清楚。使用大鼠新皮层切片中的配对记录，我们发现快速刺激性细胞的发射可以反映单轴金字塔输入的尖峰模式。此外，该特性允许通过电和γ-氨基丁酸（GABA） - 释放（GABA能）突触相互连接的快速加速细胞，以检测其兴奋性输入的相对时间。这些结果表明，快速加速细胞的网络可能在新皮层内的同步活动的检测和促进中起作用。
The temporal pattern and relative timing of action potentials among neocortical neurons may carry important information. However, how cortical circuits detect or generate coherent activity remains unclear. Using paired recordings in rat neocortical slices, we found that the firing of fast-spiking cells can reflect the spiking pattern of single-axon pyramidal inputs. Moreover, this property allowed groups of fast-spiking cells interconnected by electrical and gamma -aminobutyric acid (GABA)-releasing (GABAergic) synapses to detect the relative timing of their excitatory inputs. These results indicate that networks of fast-spiking cells may play a role in the detection and promotion of synchronous activity within the neocortex.