Small intestinal submucosa as a vascular graft: a review.
Small intestinal submucosa as a vascular graft: a review.
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DOI：
10.3109/08941939309141619
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发表时间：
1993-05-01
期刊：
影响因子：
--
通讯作者：
Morff, R J
中科院分区：
文献类型：
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作者：
Lantz, G C;Badylak, S F;Morff, R J
血管移植材料的持续调查表明，不可接受的移植并发症继续，理想的移植材料尚未被发现。我们已经开发和测试了一种生物血管移植材料，小肠粘膜下层（SIS），在正常的狗。当用作自体移植物、同种异体移植物或异种移植物时，该材料已证明在主动脉、颈动脉和股动脉以及上级腔静脉位置具有生物相容性和高通畅率。移植物在植入后28天完全内皮化。在90天时，移植物在组织学上与正常动脉和静脉相似，并含有平滑肌中膜和致密的纤维结缔组织外膜。长达5年的随访期未发现感染、内膜增生或动脉瘤扩张的证据。一项感染-挑战研究表明，SIS可能具有抗感染性，这可能是因为SIS的早期毛细血管渗透（植入后2 - 4天）和将身体防御输送到局部部位。我们的结论是SIS是一种合适的血液界面材料，值得继续研究。它可以作为一个结构框架的组织工程技术的应用，在难以捉摸的理想血管移植材料的发展。
Continuing investigations of vascular graft materials suggest that unacceptable graft complications continue and that the ideal graft material has not yet been found. We have developed and tested a biologic vascular graft material, small intestine submucosa (SIS), in normal dogs. This material, when used as an autograft, allograft, or xenograft has demonstrated biocompatibility and high patency rates in aorta, carotid and femoral arteries, and superior vena cava locations. The grafts are completely endothelialized at 28 days post-implantation. At 90 days, the grafts are histologically similar to normal arteries and veins and contain a smooth muscle media and a dense fibrous connective tissue adventitia. Follow-up periods of up to 5 years found no evidence of infection, intimal hyperplasia, or aneurysmal dilation. One infection-challenge study suggested that SIS may be infection resistant, possibly because of early capillary penetration of the SIS (2 to 4 days after implantation) and delivery of body defenses to the local site. We conclude that SIS is a suitable blood interface material and is worthy of continued investigation. It may serve as a structural framework for the application of tissue engineering technologies in the development of the elusive ideal vascular graft material.