Meibomian Gland Features and Conjunctival Goblet Cell Density in Glaucomatous Patients Controlled With Prostaglandin/Timolol Fixed Combinations: A Case Control, Cross-sectional Study
Meibomian Gland Features and Conjunctival Goblet Cell Density in Glaucomatous Patients Controlled With Prostaglandin/Timolol Fixed Combinations: A Case Control, Cross-sectional Study
复制标题
DOI：
10.1097/ijg.0000000000000899
复制
发表时间：
2018-04-01
影响因子：
2
通讯作者：
Mastropasqua, Leonardo
中科院分区：
文献类型：
--
作者：
Agnifili, Luca;Mastropasqua, Rodolfo;Mastropasqua, Leonardo
目的：探讨前列腺素/噻吗洛尔固定复方制剂（PTFCs）治疗后结膜昏迷患者的睑板腺（MG）特征和结膜杯状细胞密度（GCD）的变化。材料和方法：在这项横断面研究中，60例白色患者接受PTFCs治疗，15例患者接受拉坦前列素+噻吗洛尔（L+T）非固定复方制剂治疗，15例患者接受对照。患者接受了眼表疾病指数问卷调查、泪膜破裂时间、角膜染色、Schirmer试验I以及MG和杯状细胞的IVCM。主要结果指标为：平均睑板腺泡密度（MMAD）和面积（MMAA），腺泡壁（InAW）和腺泡壁（InI）的不均匀性，以及GCD.Results：PTFC为：拉坦前列素/噻吗洛尔（LTFC，15只眼），曲伏前列素/噻吗洛尔（TTFC，15只眼），比马前列素/噻吗洛尔（BTFC，15只眼），和无前列腺素比马前列素/噻吗洛尔（PF-BTFC，15只眼）固定组合。治疗组间的平均治疗时间无差异。IVCM记录了较低的GCD、MMAD和MMAA（P
Purpose:To investigate, using in vivo confocal microscopy (IVCM), the Meibomian gland (MG) features and conjunctival goblet cell density (GCD) in glaucomatous patients controlled with prostaglandin/timolol fixed combinations (PTFCs).Materials and Methods:In this cross-sectional study, 60 white patients were treated with PTFCs, 15 with latanoprost+timolol (L+T) unfixed combination, and 15 controls were enrolled. Patients underwent the Ocular Surface Disease Index questionnaire, tear film breakup time, corneal staining, Schirmer test I, and IVCM of MGs and goblet cells. The main outcome measures were: mean Meibomian acinar density (MMAD) and area (MMAA), inhomogeneity of glandular interstice (InI) and acinar wall (InAW), and GCD.Results:PTFCs were: latanoprost/timolol (LTFC, 15 eyes), travoprost/timolol (TTFC, 15), bimatoprost/timolol (BTFC, 15), and preservative-free bimatoprost/timolol (PF-BTFC, 15) fixed combinations. Mean time on therapy did not differ among treatments. IVCM documented lower GCD, MMAD, and MMAA (P