Analgesic efficacy of intra-articular morphine in experimentally induced radiocarpal synovitis in horses
Analgesic efficacy of intra-articular morphine in experimentally induced radiocarpal synovitis in horses
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DOI：
10.1111/j.1467-2995.2009.00521.x
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发表时间：
2010-03-01
影响因子：
1.7
通讯作者：
Andersen, Pia H.
中科院分区：
文献类型：
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作者：
Lindegaard, Casper;Thomsen, Maj H.;Andersen, Pia H.
目的是比较具有实验诱导的滑膜炎的马中关节内（IA）和静脉内（IV）吗啡的镇痛作用。八匹马马匹。进行造成的，观察者，观察者盲目，双假试验，具有顺序的交叉设计。通过IA注射脂多糖诱导的两次3周的冲洗期。在一个研究期间，马接受治疗；吗啡IA（0.05 mg kg（-1））加盐水IV，在其他研究期间，他们接受了治疗IV；盐水IA加吗啡IV（0.05 mg kg）1）。在两个168小时的研究期中，两个观察者反复评估了la行和疼痛。通过使用视觉模拟量表（VAS）和复合量度疼痛量表（CMP）来评估疼痛。通过重复测量的方差分析进行处理的比较。显着性水平设置为p
Objective To compare the analgesic effect of intra-articular (IA) and intravenous (IV) morphine in horses with experimentally induced synovitis.Animals Eight adult horses.Study design Randomized, observer blinded, double dummy trial with sequential crossover design.Methods Radiocarpal synovitis was induced by IA injection of lipopolysaccharide on two occasions separated by a 3-week washout period. In one study period horses received treatment IA; morphine IA (0.05 mg kg(-1)) plus saline IV and in the other study period they received treatment IV; saline IA plus morphine IV ( 0.05 mg kg) 1). Lameness and pain were evaluated repeatedly by two observers throughout each of the two 168-hour study periods. Pain was evaluated by use of a visual analogue scale of pain intensity ( VAS) and a composite measure pain scale ( CMPS). Comparison of treatments was performed by analysis of variance with repeated measurements. Significance level was set to p