CREB AS A MEMORY MODULATOR - INDUCED EXPRESSION OF A DCREB2 ACTIVATOR ISOFORM ENHANCES LONG-TERM-MEMORY IN DROSOPHILA
CREB AS A MEMORY MODULATOR - INDUCED EXPRESSION OF A DCREB2 ACTIVATOR ISOFORM ENHANCES LONG-TERM-MEMORY IN DROSOPHILA
复制标题
DOI：
10.1016/0092-8674(95)90375-5
复制
发表时间：
1995-04-07
期刊：
影响因子：
64.5
通讯作者：
TULLY, T
中科院分区：
文献类型：
--
作者：
YIN, JCP;DELVECCHIO, M;TULLY, T
果蝇记忆形成的遗传学研究表明，蛋白质合成依赖的长期记忆（LTM）的形成需要多次训练。LTM通过cAMP反应元件结合蛋白（CREB）的阻遏物同种型的诱导表达而特异性阻断。在这里，我们报告了一个增强的LTM形成后，诱导表达的激活剂亚型dCREB 2。在一次训练后达到最大LTM，并且其形成取决于激活剂转基因的磷酸化。提出了一个基于CREB亚型差异调节的LTM形成模型。
Genetic studies of memory formation in Drosophila have revealed that the formation of a protein synthesis-dependent long-term memory (LTM) requires multiple training sessions. LTM is blocked specifically by induced expression of a repressor isoform of the cAMP-responsive element-binding protein (CREB). Here, we report an enhancement of LTM formation after induced expression of an activator isoform of dCREB2. Maximum LTM is achieved after one training session, and its formation depends on phosphorylation of the activator transgene. A model of LTM formation based on differential regulation of CREB isoforms is proposed.