Facilitating Translational Nanomedicine via Predictive Safety Assessment
Facilitating Translational Nanomedicine via Predictive Safety Assessment
复制标题
DOI：
10.1016/j.ymthe.2017.03.011
复制
发表时间：
2017-07-05
影响因子：
12.4
通讯作者：
Xia, Tian
中科院分区：
文献类型：
--
作者：
Mirshafiee, Vahid;Jiang, Wen;Xia, Tian
对工程纳米材料（ENM）的广泛研究导致了许多用于治疗诊断目的的纳米制剂的开发。尽管市场上已经存在一些基于纳米的药物递送系统，但越来越多的新设计的ENM表现出改善的理化性质，并正在临床前阶段进行评估。虽然这些ENM旨在提高当前基于纳米的治疗或成像系统的功效，但有必要彻底确定其安全性以成功应用于临床。因此，我们在本次小型综述中的目的是讨论目前对开发阶段主要ENM的预测安全性和构效关系（SAR）分析的认识，以及额外长期毒理学分析的必要性，这将有助于促进其向临床实践的过渡。我们专注于这些纳米材料与细胞的相互作用将如何触发信号通路作为导致不良后果的分子启动事件。这些机制的理解将有助于设计更安全的ENM，提高临床治疗效果。
Extensive research on engineered nanomaterials (ENMs) has led to the development of numerous nano-based formulations for theranostic purposes. Although some nano-based drug delivery systems already exist on the market, growing numbers of newly designed ENMs exhibit improved physicochemical properties and are being assessed in preclinical stages. While these ENMs are designed to improve the efficacy of current nano based therapeutic or imaging systems, it is necessary to thoroughly determine their safety profiles for successful clinical applications. As such, our aim in this mini-review is to discuss the current knowledge on predictive safety and structure-activity relationship (SAR) analysis of major ENMs at the developing stage, as well as the necessity of additional long-term toxicological analysis that would help to facilitate their transition into clinical practices. We focus on how the interaction of these nanomaterials with cells would trigger signaling pathways as molecular initiating events that lead to adverse outcomes. These mechanistic understandings would help to design safer ENMs with improved therapeutic efficacy in clinical settings.