Regulatory expression of components in the BMP pathway in white adipose tissues of cattle
Regulatory expression of components in the BMP pathway in white adipose tissues of cattle
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DOI：
10.1016/j.livsci.2015.02.008
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发表时间：
2015-04
影响因子：
1.8
通讯作者：
Yuhang Qiao;Tomoya Yamada;Yohei Kanamori;R. Kida;Mei Shigematsu;Yusuke Fujimoto;Shozo Tomonaga;T. Matsui;M. Funaba
中科院分区：
文献类型：
--
作者：
Yuhang Qiao;Tomoya Yamada;Yohei Kanamori;R. Kida;Mei Shigematsu;Yusuke Fujimoto;Shozo Tomonaga;T. Matsui;M. Funaba
BMP途径正调控鼠棕色脂肪形成。我们在此检测了不同精粗比日粮或维生素A缺乏日粮的牛脂肪组织中BMP和激活素βB以及BMP途径受体的mRNA水平。在饲喂精料饲料的动物的皮下脂肪库中，激活素βB的表达显著增加，而维生素A缺乏饲料显著增加肠系膜脂肪库中BMP 4的表达。BMP途径的受体ALK 2、ALK 3、ActRIIA和BMPR 2的表达在对饮食处理的响应中显示出与BMP 4和激活素βB相似的模式。本研究的结果表明，饮食调制的BMP途径的组件的表达，并可能是负责棕色/米色脂肪细胞相关基因在牛的脂肪组织中的调节表达。
The BMP pathway positively regulates murine brown adipogenesis. We herein examined the mRNA levels of BMPs and activin βB as well as receptors for the BMP pathway in the adipose tissues of cattle fed diets with a differential ratio of concentrate to roughage or a vitamin A-deficient diet. The expression of activin βB was significantly increased in the subcutaneous fat depot of animals fed the concentrate diet, while the vitamin A-deficient diet significantly increased the expression of BMP4 in the mesenteric fat depot. The expression of receptors for the BMP pathway, ALK2, ALK3, ActRIIA, and BMPR2, showed a similar pattern to that of BMP4 and activin βB in response to the dietary treatments. The results of the present study demonstrated that diet modulated the expression of components of the BMP pathway and may be responsible for the regulatory expression of brown/beige adipocyte-related genes in the adipose tissues of cattle.